Netherlands Twin Register: From twins to twin families
Netherlands Twin Register: From twins to twin families
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DOI：
10.1375/183242706779462426
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发表时间：
2006-12-01
影响因子：
0.9
通讯作者：
Willemsen, Gonneke
中科院分区：
文献类型：
--
作者：
Boomsma, Dorret I.;de Geus, Eco J. C.;Willemsen, Gonneke
在1980年代后期，荷兰双胞胎登记处（NTR）通过招募出生时的年轻双胞胎和多胞胎，并通过市议会接触青少年和年轻成年双胞胎而建立。成人NTR（ANTR）包括双胞胎，他们的父母，兄弟姐妹，配偶和他们的成年后代。参加国家技术研究所调查和/或实验室研究的人数超过22，000人。一个特殊的参与者群体由双胞胎的母亲姐妹篇组成。在年轻的NTR（YNTR），数据超过50,000年轻的双胞胎已经收集。目前，我们正在通过包括双胞胎的兄弟姐妹来扩展YNTR。自1986年和1991年以来，YNTR和ANTR的参与者分别每2至3年在纵向调查研究中进行一次表型分析。由此产生的大量基于人群的数据集被用于遗传流行病学研究，也被用于例如通过基于来自其他清单的现有项目开发新的综合征量表来推进表型分析。新的研究进展还包括在选定的和非选定的群体中进行脑成像研究，通过访谈进行精神病理学的临床评估，以及将NTR数据库与其他国家数据库进行交叉引用。ANTR正在进行一项大型生物库企业，其中收集血液和尿液样本用于基因分型、表达分析和代谢组学研究。在本文中，我们给出了更新的YNTR和ANTR表型和正在进行的ANTR生物库研究。
In the late 1980s The Netherlands Twin Register (NTR) was established by recruiting young twins and multiples at birth and by approaching adolescent and young adult twins through city councils. The Adult NTR (ANTR) includes twins, their parents, siblings, spouses and their adult offspring. The number of participants in the ANTR who take part in survey and / or laboratory studies is over 22,000 subjects. A special group of participants consists of sisters who are mothers of twins. In the Young NTR (YNTR), data on more than 50,000 young twins have been collected. Currently we are extending the YNTR by including siblings of twins. Participants in YNTR and ANTR have been phenotyped every 2 to 3 years in longitudinal survey studies, since 1986 and 1991 for the YNTR and ANTR, respectively. The resulting large population-based datasets are used for genetic epidemiological studies and also, for example, to advance phenotyping through the development of new syndrome scales based on existing items from other inventories. New research developments further include brain imaging studies in selected and unselected groups, clinical assessment of psychopathology through interviews, and cross-referencing the NTR database to other national databases. A large biobank enterprise is ongoing in the ANTR in which blood and urine samples are collected for genotyping, expression analysis, and metabolomics studies. In this paper we give an update on the YNTR and ANTR phenotyping and on the ongoing ANTR biobank studies.