Rickettsia buchneri, symbiont of the deer tick Ixodes scapularis, can colonise the salivary glands of its host
Rickettsia buchneri, symbiont of the deer tick Ixodes scapularis, can colonise the salivary glands of its host
复制标题
DOI：
10.1016/j.ttbdis.2019.101299
复制
发表时间：
2020-01-01
影响因子：
3.2
通讯作者：
Makepeace, Benjamin L.
中科院分区：
文献类型：
--
作者：
Al-Khafaji, Alaa M.;Armstrong, Stuart D.;Makepeace, Benjamin L.
垂直传播的细菌共生体在蜱中广泛存在，对蜱传疾病的流行病学有多方面的影响。例如，它们可以为蜱提供必需的营养素，影响载体能力，诱导脊椎动物宿主的免疫反应，甚至进化成为脊椎动物病原体。鹿或黑脚蜱肩胛硬蜱在其卵巢组织中携带共生体布氏立克次体。本研究通过分子生物学、蛋白质组学和影像学等方法证明了R. Buchneri也能够定殖在野生I.肩胛肌这一发现对立克次体感染的诊断和这种臭名昭著的莱姆病载体中的病原体-共生体相互作用具有重要意义。
Vertically-transmitted bacterial symbionts are widespread in ticks and have manifold impacts on the epidemiology of tick-borne diseases. For instance, they may provide essential nutrients to ticks, affect vector competence, induce immune responses in vertebrate hosts, or even evolve to become vertebrate pathogens. The deer or blacklegged tick Ixodes scapularis harbours the symbiont Rickettsia buchneri in its ovarian tissues. Here we show by molecular, proteomic and imaging methods that R. buchneri is also capable of colonising the salivary glands of wild I. scapularis. This finding has important implications for the diagnosis of rickettsial infections and for pathogen-symbiont interactions in this notorious vector of Lyme borreliosis.