Increased expression of long pentraxin PTX3 in inflammatory bowel diseases
Increased expression of long pentraxin PTX3 in inflammatory bowel diseases
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DOI：
10.1007/s10620-007-0075-z
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发表时间：
2008-07-01
影响因子：
3.1
通讯作者：
Yakabi, Koji
中科院分区：
文献类型：
--
作者：
Kato, Shingo;Ochiai, Mitsuko;Yakabi, Koji
本研究的目的是研究炎症性肠病患者炎症性胃肠道组织中戊traxin-3的表达，并阐明血浆戊traxin-3水平作为炎症性肠病患者炎症标志物的有效性。炎症肠内浸润性中性粒细胞和血管中发现了戊烷素-3免疫反应性。活动性炎症性肠病患者血浆戊曲辛-3浓度明显高于正常人和非活动性炎症性肠病患者。炎症性肠病患者的临床疾病活动性与血浆戊曲辛-3浓度和血清CRP浓度呈正相关。在炎症性肠病中，pentaxin -3是由发炎的肠道直接产生的。综上所述，血浆戊烷素-3浓度是了解炎症性肠病患者疾病活动性的有用指标。
The aims of this study were to investigate the expression of pentraxin-3 in inflamed gastrointestinal tissue in patients with inflammatory bowel diseases and to elucidate the usefulness of plasma pentraxin-3 level as an inflammation marker in patients with inflammatory bowel diseases. Pentraxin-3 immunoreactivity was found in infiltrating neutrophils and vessels in the inflamed gut. Plasma pentraxin-3 concentration in patients with active inflammatory bowel diseases was significantly higher than that of normal subjects and patients with inactive inflammatory bowel diseases. Significant positive correlations of clinical disease activity with plasma pentraxin-3 concentration and serum CRP concentration were found in patients with inflammatory bowel diseases. Pentraxin-3 is directly produced from the inflamed gut in inflammatory bowel diseases. In conclusion, plasma pentraxin-3 concentration is a useful marker for understanding the disease activity in patients with inflammatory bowel diseases.