Effect of obesity and other lifestyle factors on mortality in women with breast cancer
Effect of obesity and other lifestyle factors on mortality in women with breast cancer
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DOI：
10.1002/ijc.23747
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发表时间：
2008-11-01
影响因子：
6.4
通讯作者：
Franceschi, Silvia
中科院分区：
文献类型：
--
作者：
Dal Maso, Luigino;Zucchetto, Antonella;Franceschi, Silvia
一些生活方式的特点，癌症诊断前已建议修改乳腺癌的预后。在意大利一项多中心病例对照研究的框架内，对1991年至1994年诊断为侵袭性乳腺癌的1,453名妇女进行了随访，以评估肥胖和其他4个大范围因素对乳腺癌死亡率的影响。确定了503例死亡，包括398例乳腺癌死亡。使用考克斯比例风险模型计算全因和乳腺癌死亡率的风险比（HR）和相应的95%置信区间（CI），并根据年龄和乳腺癌特征（分期和受体状态）进行校正。与体重指数≥ 30 kg/m2（HR = 1.38; 95% CI：1.02-1.86）的女性相比，体重指数≥ 30 kg/m2（HR = 1.27; 95% CI：0.98-1.64）的女性乳腺癌死亡风险增加（HR = 1.38; 95% CI：1.02-1.86），与体重指数≥ 30和高WHR（>= 0.85）的女性相比，
A few lifestyle characteristics before cancer diagnosis have been suggested to modify the prognosis of breast cancer. Follow-up information from 1,453 women with incident invasive breast cancer, diagnosed between 1991 and 1994 and interviewed within the framework of an Italian multicenter case-control study, was used to assess the effect of obesity and of a large spectrum 4 other factors on breast cancer mortality. Five hundred and three deaths, including 398 breast cancer deaths, were identified. Hazard ratios (HR) for all-cause and breast cancer mortality and corresponding 95% confidence intervals (CI), were calculated using Cox proportional hazards models and adjusted for age and breast cancer characteristics (stage and receptor status). Increased risk of death for breast cancer emerged for body mass index (BMI) >= 30 kg/m(2) (HR = 1.38; 95% CI: 1.02-1.86), compared to = 0.85 (HR = 1.27; 95% CI: 0.98-1.64), compared to = 30 and high WHR (>= 0.85), compared to women with BMI