fastsimcoal: a continuous-time coalescent simulator of genomic diversity under arbitrarily complex evolutionary scenarios
fastsimcoal: a continuous-time coalescent simulator of genomic diversity under arbitrarily complex evolutionary scenarios
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DOI：
10.1093/bioinformatics/btr124
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发表时间：
2011-05-01
期刊：
影响因子：
5.8
通讯作者：
Foll, Matthieu
中科院分区：
文献类型：
--
作者：
Excoffier, Laurent;Foll, Matthieu
动机：遗传学研究的重点是现存和古代 DNA 中越来越大的基因组区域，并且需要模拟软件来匹配这些技术进步。我们在这里提出了一种新的基于聚结的模拟程序fastsimcoal，它能够快速模拟分散在很长的基因组区域中的各种遗传标记，在复杂的进化场景下具有任意重组模式。
Motivation: Genetic studies focus on increasingly larger genomic regions of both extant and ancient DNA, and there is a need for simulation software to match these technological advances. We present here a new coalescent-based simulation program fastsimcoal, which is able to quickly simulate a variety of genetic markers scattered over very long genomic regions with arbitrary recombination patterns under complex evolutionary scenarios.