Turning off the alarm - Targeting alarmins and other epithelial mediators of allergic inflammation with biologics.
Turning off the alarm - Targeting alarmins and other epithelial mediators of allergic inflammation with biologics.
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DOI：
10.5414/alx02194e
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Albrecht M
中科院分区：
文献类型：
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作者：
Albrecht M
除了主要的IL-4、IL-13、IL-5和IgE作为生物制剂的靶标外，还发现了其他由上皮细胞分泌的介质，它们在过敏性炎症的级联反应中起上游作用。IL-33、TSLP和IL-5都有警示作用。每种细胞因子在过敏性炎症的致敏和效应阶段的作用，以及如何开发生物制剂来抑制这一病理机制，将在以下文章中描述。
Besides the major players IL-4, IL-13, IL-5, and IgE as targets for biologics, other mediators have been identified that are secreted by epithelial cells and act upstream in the cascade of allergic inflammation. Such are the alarmin IL-33 as well as TSLP and IL-5. The role of each cytokine in sensitization and effector phase of allergic inflammation and how development of biologics is ongoing in order to inhibit this pathomechanism will be described in the following article.