Knowledge, expectations and fears of cannabis use of epilepsy patients at a tertiary epilepsy center
Knowledge, expectations and fears of cannabis use of epilepsy patients at a tertiary epilepsy center
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DOI：
10.1016/j.yebeh.2019.106458
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发表时间：
2019-10-01
影响因子：
2.6
通讯作者：
Helmstaedter, Christoph
中科院分区：
文献类型：
--
作者：
von Wrede, Randi;Moskau-Hartmann, Susanna;Helmstaedter, Christoph
导言：医用大麻越来越多地被讨论为神经系统疾病（如癫痫）的替代治疗选择。支持者和反对者的主张主要基于主观估计，他们混淆了大麻整体与提取物、植物性与合成性。方法：275名患有任何类型癫痫的患者（56%女性，44%无癫痫发作，91%服用药物）回答了一项关于知识、期望、恐惧和接受医用大麻治疗的意愿的调查。数据进行了分析，患者的特点和临床数据从patient files.Results：总体而言，70.5%的患者熟悉的可能性，医用大麻治疗，36.7%，其使用在癫痫。10.9%的少数人从他们的医生那里获得信息。与合成大麻相比，大多数人都知道有机大麻。对进一步信息的兴趣很高（71.3%）。回归分析（解释53.8%的方差）表明，积极的期望（在相关性的顺序）癫痫控制，放松，情绪和耐受性，而恐惧主要涉及成瘾和delirant中毒。男性表现出更大的兴趣比women.Conclusion：许多癫痫患者知道医用大麻，有兴趣在这种治疗，并希望更多的信息。然而，人们的期望似乎是基于含有四氢大麻二酚的整个大麻物质的内涵及其众所周知的效果。不幸的是，患者并不是从医生那里获得信息，而是主要通过其他来源。为了避免偏见和可能有害的自我药疗，医生和医疗保健提供者被要求熟悉该物质并充分告知患者。(c)2019爱思唯尔公司All rights reserved.
Introduction: Medical cannabis is increasingly discussed as an alternative treatment option in neurological diseases, e.g. epilepsy. Supporters and opponents base their propositions mostly on subjective estimates, they confuse cannabis in whole versus extracts and botanical versus synthesized.Methods: Two hundred seventy five patients with any kind of epilepsy (56% female, 44% seizure free, 91% on medication) answered a survey on the knowledge, expectations, fears, and willingness to be treated with medical cannabis. Data were analyzed with regard to patient characteristics and clinical data from patient files.Results: Overall, 70.5% of the patients were familiar with the possibility of medical cannabis treatment, 36.7% with its use in epilepsy. A minority of 10.9% gained the information from their physicians. The majority knew about organic compared to synthetic cannabis. The interest in further information is high (71.3%). Regression analysis (explaining 53.8% of the variance) indicated that positive expectations (in the order of relevance) were seizure control, relaxation, mood, and tolerability whereas fears mostly concerned addiction and delirant intoxication. Men showed a greater interest than women.Conclusion: Many epilepsy patients knew about medical cannabis, were interested in this treatment, and wanted more information. Expectations, however, appear to be based on the connotations of the whole substance cannabis with tetrahydrocannabidiol and its commonly known effects. Unfortunately, patients did not get their information from physicians, but mostly by other sources. In order to avoid prejudices and potentially harmful self-medication, physicians and healthcare providers are called to become familiar with the substance and to inform patients adequately. (c) 2019 Elsevier Inc. All rights reserved.