On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol.
On the utilization of the induced pluripotent stem cell (iPSC) model to study substance use disorders: A scoping review protocol.
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DOI：
10.1371/journal.pone.0292238
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
诱导多能干细胞（iPSC）是通过重编程技术从体细胞衍生的细胞。在过去的十年中，iPSC方法越来越多地用于神经精神病学研究。物质使用障碍（substance use disorders，SUDs）是一种常见的精神疾病，但iPSC模型在成瘾研究中的应用受到限制。没有全面审查的报告。我们进行了范围审查，以整理现有的iPSC技术应用于SUD研究的证据。我们的目标是确定目前的知识差距和局限性，以推进iPSC在SUD领域的使用。我们采用了由Arksey和O 'Malley首次创建并由Levac等人和Joanna Briggs Institute（JBI）进一步更新的方法框架进行范围审查。我们采用了方案系统性综述和荟萃分析扩展的首选报告项目（PRISMA-P）来报告方案的项目。我们从四个电子数据库中检索证据：PubMed®、Embase®、Web of Science™和Scopus®。纳入了初步研究、系统性综述和荟萃分析，并仅限于2007年至2022年3月期间以英语发表的研究。这是一项“正在进行的”范围界定审查。检索的研究将由两名审查员独立筛选、选择和提取。分歧将由第三次评审和讨论解决。提取的数据将以描述性和定量方法进行分析，然后以适当的格式进行总结和展示。结果将按照系统性综述和荟萃分析扩展范围综述（PRISMA-ScR）指南的首选报告项目进行报告，并通过同行评审出版物和会议报告进行传播。据我们所知，这是第一次对iPSC方法进行全面的范围审查，该方法专门适用于导致SUD或滥用行为的各种成瘾药物/物质。该协议在Zenodo存储库（https：//zenodo.org/）上注册，doi为10.5281/zenodo.7915252。
Induced pluripotent stem cells (iPSCs) are cells derived from somatic cells via reprogramming techniques. The iPSC approach has been increasingly used in neuropsychiatric research in the last decade. Though substance use disorders (SUDs) are a commonly occurring psychiatric disorder, the application of iPSC model in addiction research has been limited. No comprehensive review has been reported. We conducted a scoping review to collate existing evidence on the iPSC technologies applied to SUD research. We aim to identify current knowledge gaps and limitations in order to advance the use of iPSCs in the SUD field. We employed a scoping review using the methodological framework first created by Arksey and O’Malley and further updated by Levac et al. and the Joanna Briggs Institute (JBI). We adopted the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Protocols (PRISMA-P) to report items for the protocol. We searched evidence from four electronic databases: PubMed®, Embase®, Web of Science™, and Scopus®. Primary research, systematic reviews, and meta-analyses were included and limited to studies published in English, at the time from 2007 to March 2022. This is an “ongoing” scoping review. Searched studies will be independently screened, selected, and extracted by two reviewers. Disagreement will be solved by the third reviewer and discussion. Extracted data will be analyzed in descriptive and quantitative approaches, then summarized and presented in appropriate formats. Results will be reported following the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guideline and disseminated through a peer-reviewed publication and conference presentations. To our best knowledge, this is the first comprehensive scoping review of iPSC methods specifically applied to a broad range of addictive drugs/substances that lead to SUDs or misuse behavior. This protocol is registered on Zenodo repository (https://zenodo.org/) with doi:10.5281/zenodo.7915252.
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DOI：
10.1007/s00335-017-9684-9
发表时间：
2017-08
期刊：
Mammalian genome : official journal of the International Mammalian Genome Society
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