Breastfeeding improves dynamic reorganization of functional connectivity in preterm infants: a temporal brain network study
Breastfeeding improves dynamic reorganization of functional connectivity in preterm infants: a temporal brain network study
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母乳喂养改善早产儿功能连接的动态重组：一项颞脑网络研究
DOI：
10.1007/s11517-020-02244-3
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发表时间：
2020-09-18
影响因子：
3.2
通讯作者：
Sun, Yu
中科院分区：
文献类型：
--
作者：
Niu, Weiming;Xu, Xinfen;Sun, Yu
大量证据表明，母乳喂养对婴儿在更好的营养和神经发育结果方面有好处。然而，早产儿的大脑发育和喂养之间的关系，谁是生理和发育不成熟的出生时，才开始进行定量评估，与最近出现的神经成像技术相吻合。在目前的工作中，我们研究了50例早产儿的样本，出生在胎龄29至33周（32.20 ± 0.89周）之间，其中30例母乳喂养，其余20例配方奶粉喂养。在镇静状态下，使用1.5-T扫描仪记录了大约相当于足月年龄（40.00 ± 1.31周，范围39-44周）的静息状态功能磁共振成像（fMRI）。时间脑网络的估计滑动时间窗的时间课程之间的相关性的区域的预定义的图集。通过我们新引入的时间效率方法，我们第一次研究了颞脑网络的3D时空结构。我们在两组中都发现了显著的时间小世界特性，这表明动态功能连接的安排允许各个大脑区域随着时间的推移在局部和全局水平上进行有效的信息传输。更重要的是，我们发现母乳喂养的早产儿比配方奶粉喂养的早产儿表现出更大的时间整体效率。具体来说，我们发现右侧颞回和双侧尾状核的颞结属性局部升高。这些研究结果为母乳促进婴儿早期大脑发育和认知功能提供了新的证据，这可能对父母和儿科医生产生神经生物学和公共卫生方面的影响。母乳喂养长期以来一直被认为对婴儿早期神经发育有有益的影响。然而，母乳喂养对早产儿功能连接重组的影响在很大程度上是未知的。为此，我们利用我们最近开发的颞脑网络分析框架，研究母乳喂养的早产儿脑功能连接的动态重组。我们发现，除了一个最佳的时间小世界拓扑结构，母乳喂养的早产儿表现出改善的网络效率在全球和区域水平相比，配方奶粉喂养的infants.Graphical摘要：母乳喂养长期以来一直被认为对婴儿早期神经发育的有益影响。然而，母乳喂养对早产儿脑功能连接重组的影响在很大程度上是未知的。为此，我们利用我们最近开发的颞脑网络分析框架，研究母乳喂养的早产儿的功能连接的动态重组。我们发现，除了一个最佳的时间小世界拓扑结构，母乳喂养的早产儿表现出改善的网络效率在全球和区域水平相比，配方奶粉喂养的婴儿。
Substantial evidences have shown the benefits of breastfeeding to infants in terms of better nutrition and neurodevelopmental outcome. However, the relationship between brain development and feeding in preterm infants, who are physiologically and developmentally immature at birth, is only beginning to be quantitatively assessed, coinciding with the recent advent of neuroimaging techniques. In the current work, we studied a sample of 50 preterm infants—born between 29 and 33 weeks (32.20 ± 0.89 weeks) of gestational age, where 30 of them were breastfed and the remaining 20 were formula-fed. Resting-state functional magnetic resonance imaging (fMRI) was recorded around term-equivalent age (40.00 ± 1.31 weeks, range 39–44 weeks) using a 1.5-T scanner under sedation condition. Temporal brain networks were estimated by the correlation of sliding time-window time courses among regions of a predefined atlas. Through our newly introduced temporal efficiency approach, we examined, for the first time, the 3D spatiotemporal architecture of the temporal brain network. We found prominent temporal small-world properties in both groups, suggesting the arrangement of dynamic functional connectivity permits effective coordination of various brain regions for efficient information transfer over time at both local and global levels. More importantly, we showed that breastfed preterm infants exhibited greater temporal global efficiency in comparison with formula-fed preterm infants. Specifically, we found localized elevation of temporal nodal properties in the right temporal gyrus and bilateral caudate. Taken together, these findings provide new evidence to support the notion that breast milk promotes early brain development and cognitive function, which may have neurobiological and public health implications for parents and pediatricians.Breastfeeding has long been recognized to have beneficial effect on early neurodevelopment in infants. However, the influence of breastfeeding on reorganization of functional connectivity in preterm infants are largely unknown. To this end, we utilized our recently developed temporal brain network analysis framework to investigate the dynamic reorganization of brain functional connectivity in preterm infants fed with breast milk. We found that beyond an optimal temporal small-world topology, breastfed preterm infants exhibited improved network efficiency at both global and regional levels in comparisons with those of formula-fed infants.Graphical abstract:Breastfeeding has long been recognized to have beneficial effect on early neurodevelopment in infants. However, the influence of breastfeeding on reorganization of brain functional connectivity in preterm infants are largely unknown. To this end, we utilized our recently developed temporal brain network analysis framework to investigate the dynamic reorganization of functional connectivity in preterm infants fed with breast milk. We found that beyond an optimal temporal small-world topology, breastfed preterm infants exhibited improved network efficiency at both global and regional levels in comparisons with those of formula-fed infants.