COMPARISON OF REDUCED ALKYLATED DERIVATIVES OF SOME MYELOMA GLOBULINS AND BENCE-JONES PROTEINS
COMPARISON OF REDUCED ALKYLATED DERIVATIVES OF SOME MYELOMA GLOBULINS AND BENCE-JONES PROTEINS
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DOI：
10.1038/1911274a0
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发表时间：
1961-01-01
期刊：
影响因子：
64.8
通讯作者：
EDELMAN, GM
中科院分区：
文献类型：
--
作者：
POULIK, MD;EDELMAN, GM
YESMA球蛋白是异常血清蛋白，通过其相对同质性和化学特性与正常γ-球蛋白区分开。许多比较化学和免疫学研究 ** 旨在进一步阐明它们与正常γ球蛋白的关系。证明”正常和异常的γ-球蛋白家族的蛋白质在二硫键裂解后解离成可分离的亚基“使得有可能在亚基水平上比较骨髓瘤蛋白质彼此之间以及与正常-γ-球蛋白 *。本文介绍了10种人骨髓瘤球蛋白的额外数据，以及来自同一患者的骨髓瘤蛋白和Bence-Jones蛋白的一些相关实验。
YELOMA globulins are abnormal serum proteins distinguished from normal-y-globulin by their relative homogeneity and their chemical individuality. A number of comparative chemical and immunological studies** have been aimed at elucidating further their relations to normal-y-globulins. The demonstration" that normal and abnormal proteins of the y-globulin family dissociate into separable sub-units after cleavage of disulphide bonds has made it possible to compare myeloma proteins with each other and with normal-y-globulins at the level of their sub-units*. This article presents additional data on 10 human myeloma globulins and some correlative experiments on myeloma proteins and Bence-Jones proteins derived from the same patient.