Rat Hepatitis E Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient
Rat Hepatitis E Virus Linked to Severe Acute Hepatitis in an Immunocompetent Patient
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DOI：
10.1093/infdis/jiz025
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发表时间：
2019-09-15
影响因子：
6.4
通讯作者：
Johnston, Lynn
中科院分区：
文献类型：
--
作者：
Andonov, Anton;Robbins, Mark;Johnston, Lynn
戊型肝炎病毒（HEV）是发展中国家的一个主要公共卫生问题，主要通过受污染的水传播。在欧洲、日本和美国，越来越多的人畜共患戊型肝炎病例被描述，猪是主要的动物感染宿主。我们报告了一个不寻常的急性肝炎感染在以前健康的人所造成的大鼠戊型肝炎病毒与其他大鼠戊型肝炎病毒株相比，有相当大的分歧的基因组序列。大鼠戊型肝炎病毒可能是一种未被充分认识的肝炎感染原因，需要进一步研究以阐明其潜在的风险和传播方式。
Hepatitis E virus (HEV) is a major public health concern in developing countries where the primary transmission is via contaminated water. Zoonotic HEV cases have been increasingly described in Europe, Japan, and the United States, with pigs representing the main animal reservoir of infection. We report an unusual acute hepatitis infection in a previously healthy man caused by a rat HEV with a considerably divergent genomic sequence compared with other rat HEV strains. It is possible that rat HEV is an underrecognized cause of hepatitis infection, and further studies are necessary to elucidate its potential risk and mode of transmission.