An Electric-Field Responsive Microsystem for Controllable Miniaturised Drug Delivery Applications
An Electric-Field Responsive Microsystem for Controllable Miniaturised Drug Delivery Applications
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用于可控小型药物输送应用的电场响应微系统
DOI：
10.1016/j.proeng.2011.12.242
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Liu Y
中科院分区：
文献类型：
--
作者：
Liu Y
开发了一种新型的基于MEMS的药物递送装置，其由金属触点阵列组成。曲折结构的装置产生刺激药物释放的均匀电场。基于电活性水凝胶的聚合物基质响应于电刺激，并且在从制造的装置施加电场时收缩或去膨胀。不同的药物候选物可以包封在聚合物基质内。聚合物的去溶胀使得包封的药物能够从基质中释放。一旦电刺激停止，凝胶能够恢复其原始大小。通过控制电压和时间，可以精确地控制药物释放速率和剂量。受控药物递送装置可以与传感器技术集成在组合的诊断/治疗护理点装置中。
A novel MEMS based drug delivery device has been developed, consisting of an array of metallic contacts. The meander structured device created a uniform electric field which stimulates drug releases. An electro-active hydrogel based polymer matrix responds to an electrical stimulus and shrinks or de-swells on application of an electric field from the fabricated device. Different drug candidates can be encapsulated within the polymer matrix. The de-swelling of the polymer enables the encapsulated drug to be released from the matrix. The gel is able to recover its original size once electric stimulation has been stopped. By controlling the voltage and time, the drug release rate and dose can be precisely controlled. Controlled drug delivery devices may be integrated with sensor technology in combined diagnostic / therapeutic point of care devices.