Asthma induces psychiatric impairments in association with default mode and salience networks alteration: A resting-state EEG study
Asthma induces psychiatric impairments in association with default mode and salience networks alteration: A resting-state EEG study
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DOI：
10.1016/j.resp.2022.103870
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发表时间：
2022-02-16
影响因子：
2.3
通讯作者：
Raoufy, Mohammad Reza
中科院分区：
文献类型：
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作者：
Gholami-Mahtaj, Leila;Salimi, Morteza;Raoufy, Mohammad Reza
哮喘是一种慢性炎症性疾病，与精神疾病的高患病率相关。有特定的大脑网络负责情绪过程，包括两个与精神问题相关的重要网络：默认模式网络（DMN），在静息状态下更活跃，以及在结构上与DMN相连的显着网络（SN）。虽然先前的研究表明，哮喘的神经表型可以通过脑回路的神经活动来识别，但脑功能改变与哮喘引起的精神损害之间的关联仍然未知。我们的目的是评估DMN和SN活性及其与哮喘患者的精神指标和临床参数的关系。记录了38名性别和年龄匹配的受试者（19名特应性哮喘患者和19名健康受试者）在清醒和睁开眼睛的静息状态下的脑电图。计算了DMN和SN的功率谱和功能连通性。我们分别使用DASS问卷和肺功能测定法检查精神疾病（包括抑郁、焦虑和应激）和肺功能。结果显示，哮喘患者的DASS评分显著高于健康受试者。哮喘患者在两个网络中的功率和功能连接也表现出显著增强。值得注意的是，这些网络的功率增强与精神问题评分、肺功能、哮喘持续时间和哮喘控制不良相关。这些结果为改变大脑活动、精神障碍的存在和哮喘相关特征（包括肺功能）之间的关联提供了新的证据。此外，我们提供了新的见解哮喘引起的炎症反应和发展新的干预措施和治疗策略的重要性，管理过敏性炎症患者患有并发精神疾病。
Asthma is a chronic inflammatory disease associated with a high prevalence of psychiatric disorders. There are specific brain networks responsible for emotional processes, including two important networks associated with psychiatric problems: the default mode network (DMN), which is more active in the resting state, and the salience network (SN), which is structurally connected to DMN. Although previous studies suggested that neuro-phenotypes of asthma may be recognizable by the neural activity of brain circuits, an association between the brain's functional alterations and psychiatric impairments induced by asthma remains unknown. We aimed to assess DMN and SN activity and its association with psychiatric indices and clinical parameters in asthmatic patients. Electroencephalography was recorded during the resting state with an awake and eyes-open condition in thirty-eight sex and age-matched subjects (19 atopic asthma patients and 19 healthy participants). Power spectrum and functional connectivity were computed for DMN and SN. We examined psychiatric disorders (including depression, anxiety, and stress) and pulmonary function using the DASS questionnaire and spirometry test, respectively. The results showed that DASS scores were significantly higher in asthmatic patients compared to healthy subjects. Asthmatic patients also demonstrate a significant enhancement in power and functional connectivity in the two networks. Notably, these power enhancements of the networks were correlated with psychiatric problems scores, pulmonary function, asthma duration, and poor asthma control. These results introduce new evidence for the association between altered brain activity, the existence of psychiatric disorders, and asthma-related features, including pulmonary function. Also, we provide new insights into asthma-induced inflammatory response and the importance of developing novel interventions and therapeutic strategies for managing allergic inflammation patients who suffer from concurrent psychiatric disorders.