A high-density admixture scan in 1,670 African Americans with hypertension
A high-density admixture scan in 1,670 African Americans with hypertension
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DOI：
10.1371/journal.pgen.0030196
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发表时间：
2007-11-01
期刊：
影响因子：
4.5
通讯作者：
Reich, David
中科院分区：
文献类型：
--
作者：
Deo, Rahul C.;Patterson, Nick;Reich, David
高血压（HTN）是一种毁灭性的疾病，非裔美国人的发病率高于欧洲裔美国人，这激发了人们对导致这种差异的遗传变异的研究。我们报告了对导致 HTN 风险的基因进行大规模混合扫描的结果，其中我们对 1,670 名患有 HTN 的非裔美国人和 387 名对照个体进行了筛查，以寻找非洲或欧洲血统比例较高的基因组区域。没有发现与 HTN 显着相关的位点。我们还搜索了 40 个候选基因和 8 个先前报告的连锁峰的混合信号证据，但似乎没有一个对非洲裔美国人和欧洲裔美国人之间的 HTN 风险差异有重大影响。最后，我们在 Zhu 等人的混合扫描中检测到的基因座之一观察到名义关联。 2005 年（p = 0.016，6q24.3 校正了四个测试假设），尽管我们警告说，显着性很小，并且每个非洲等位基因的估计优势比为 1.19，低于原始报告的预期；因此，需要进一步开展工作来追踪这一轨迹。
Hypertension (HTN) is a devastating disease with a higher incidence in African Americans than European Americans, inspiring searches for genetic variants that contribute to this difference. We report the results of a large-scale admixture scan for genes contributing HTN risk, in which we screened 1,670 African Americans with HTN and 387 control individuals for regions of the genome with elevated proportion of African or European ancestry. No loci were identified that were significantly associated with HTN. We also searched for evidence of an admixture signal at 40 candidate genes and eight previously reported linkage peaks, but none appears to contribute substantially to the differential HTN risk between African and European Americans. Finally, we observed nominal association at one of the loci detected in the admixture scan of Zhu et al. 2005 (p = 0.016 at 6q24.3 correcting for four hypotheses tested), although we caution that the significance is marginal and the estimated odds ratio of 1.19 per African allele is less than what would be expected from the original report; thus, further work is needed to follow up this locus.