Prophylactic Use of a Probiotic in the Prevention of Colic, Regurgitation, and Functional Constipation A Randomized Clinical Trial
Prophylactic Use of a Probiotic in the Prevention of Colic, Regurgitation, and Functional Constipation A Randomized Clinical Trial
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DOI：
10.1001/jamapediatrics.2013.4367
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发表时间：
2014-03-01
期刊：
影响因子：
26.1
通讯作者：
Francavilla, Ruggiero
中科院分区：
文献类型：
--
作者：
Indrio, Flavia;Di Mauro, Antonio;Francavilla, Ruggiero
重要性婴幼儿绞痛、胃食道反流和便秘是最常见的功能性胃肠道疾病，导致婴儿出生后6个月内转诊至儿科医生，通常导致住院、饮食改变、药物使用、父母焦虑和父母失去工作天数，并带来相关的社会后果。目的探讨出生前3个月口服瑞氏乳杆菌DSM 17938是否可以减少足月新生儿绞痛、胃食道反流和便秘的发病，从而减少这些疾病的社会经济影响。
IMPORTANCE Infantile colic, gastroesophageal reflux, and constipation are the most common functional gastrointestinal disorders that lead to referral to a pediatrician during the first 6 months of life and are often responsible for hospitalization, feeding changes, use of drugs, parental anxiety, and loss of parental working days with relevant social consequences.OBJECTIVE To investigate whether oral supplementation with Lactobacillus reuteri DSM 17938 during the first 3 months of life can reduce the onset of colic, gastroesophageal reflux, and constipation in term newborns and thereby reduce the socioeconomic impact of these conditions.DESIGN A prospective, multicenter, double-masked, placebo-controlled randomized clinical trial was performed on term newborns (age