G protein signaling modulator-3: a leukocyte regulator of inflammation in health and disease.
G protein signaling modulator-3: a leukocyte regulator of inflammation in health and disease.
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发表时间：
2014-08
影响因子：
0.8
通讯作者：
M. Billard;B. Gall;K. Richards;D. Siderovski;T. Tarrant
中科院分区：
文献类型：
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作者：
M. Billard;B. Gall;K. Richards;D. Siderovski;T. Tarrant
G蛋白信号转导调节剂-3（GPSM 3），也称为G18或AGS 4，是含有一个或多个拷贝的小调控基序（称为GoLoco（或GPR）基序）的蛋白质家族的成员。GPSM 3直接与异源三聚体G蛋白的Gα和Gβ亚基相互作用，以调节由G蛋白偶联受体（GPCR）启动的下游细胞内信号，所述GPCR通过与其同源配体结合而活化。GPSM 3具有选择性的组织分布，并在免疫系统细胞中高度表达;全基因组关联研究（GWAS）最近揭示了GPSM 3中的单核苷酸多态性（SNP）与慢性炎症性疾病相关。本文综述了GPSM 3在正常和病理性免疫介导条件下的功能。
G protein signaling modulator-3 (GPSM3), also known as G18 or AGS4, is a member of a family of proteins containing one or more copies of a small regulatory motif known as the GoLoco (or GPR) motif. GPSM3 interacts directly with Gα and Gβ subunits of heterotrimeric G proteins to regulate downstream intracellular signals initiated by G protein coupled receptors (GPCRs) that are activated via binding to their cognate ligands. GPSM3 has a selective tissue distribution and is highly expressed in immune system cells; genome-wide association studies (GWAS) have recently revealed that single nucleotide polymorphisms (SNPs) in GPSM3 are associated with chronic inflammatory diseases. This review highlights the current knowledge of GPSM3 function in normal and pathologic immune-mediated conditions.