A Comparison of Hyperelastic Warping of PET Images with Tagged MRI for the Analysis of Cardiac Deformation.
A Comparison of Hyperelastic Warping of PET Images with Tagged MRI for the Analysis of Cardiac Deformation.
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DOI：
10.1155/2013/728624
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发表时间：
2013
影响因子：
7.6
通讯作者：
Gullberg GT
中科院分区：
文献类型：
--
作者：
Veress AI;Klein G;Gullberg GT
以下研究的目的是通过分析临床门控PET图像数据集，评估一种称为超弹性翘曲的可变形图像配准技术在左心室局部应变测量中的应用。两名正常男性受试者依次使用PET和标记MRI成像进行成像。使用PET图像的翘曲分析和基于MRI图像的HARP应变分析对收缩收缩进行应变预测。计算决定系数r2值，以比较每种方法产生的周向和径向应变预测。两种方法之间具有良好的一致性，两颗心脏径向应变的r2值均为0.78，而周向应变的r2值分别为0.81和0.83。应变预测差异无统计学意义（P≤0.01）。一系列的灵敏度结果表明，该方法对图像强度、随机图像噪声和纤维结构的变化相对不敏感。这项研究表明，翘曲能够提供左室收缩的应变预测，与标记MRI翘曲所提供的结果一致。
The objectives of the following research were to evaluate the utility of a deformable image registration technique known as hyperelastic warping for the measurement of local strains in the left ventricle through the analysis of clinical, gated PET image datasets. Two normal human male subjects were sequentially imaged with PET and tagged MRI imaging. Strain predictions were made for systolic contraction using warping analyses of the PET images and HARP based strain analyses of the MRI images. Coefficient of determination R 2 values were computed for the comparison of circumferential and radial strain predictions produced by each methodology. There was good correspondence between the methodologies, with R 2 values of 0.78 for the radial strains of both hearts and from an R 2 = 0.81 and R 2 = 0.83 for the circumferential strains. The strain predictions were not statistically different (P ≤ 0.01). A series of sensitivity results indicated that the methodology was relatively insensitive to alterations in image intensity, random image noise, and alterations in fiber structure. This study demonstrated that warping was able to provide strain predictions of systolic contraction of the LV consistent with those provided by tagged MRI Warping.