Osteoblast compatibility of 3D printed Co-Cr-Mo alloys with different building direction
Osteoblast compatibility of 3D printed Co-Cr-Mo alloys with different building direction
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不同构建方向3D打印Co-Cr-Mo合金的成骨细胞相容性
DOI：
10.1049/bsbt.2018.0043
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发表时间：
2019
影响因子：
--
通讯作者：
Suyalatu
中科院分区：
文献类型：
--
作者：
Satoshi Migita;Kosuke Sakashita;Suyalatu
三维（3D）金属打印是用于制造生物医学设备的有吸引力的技术。由于晶粒沿z轴方向沿着生长，所制备的3D金属打印产品的显微组织和力学性能表现出各向异性。然而，不同印刷方向对产品细胞相容性的影响尚不清楚。在本研究中，钴-铬-钼（Co-Cr-Mo）合金圆柱体分别沿沿着z轴（垂直）和x轴（水平）制备，并评估构建方向对细胞相容性的影响。3D打印Co-Cr-Mo合金的构建方向改变了晶粒各向异性;然而，晶粒尺寸没有统计学差异。垂直和水平产品圆盘上的润湿性、蛋白质吸附、细胞附着和细胞增殖与铸造合金相似;它们显著低于商业纯钛和组织培养聚苯乙烯。3D打印Co-Cr-Mo合金的构建方向不会影响成骨细胞的相容性。
Three‐dimensional (3D) metal printing is an attractive technique for fabricating biomedical devices. The microstructures and mechanical properties of the fabricated 3D metal printed products show anisotropy because the grains grow along thez‐axis direction. However, the effects of different printing directions on the cytocompatibility of the products are unknown. In the present study, cobalt–chromium–molybdenum (Co–Cr–Mo) alloy cylinders were fabricated along thez‐axis (vertical) andx‐axis (horizontal), respectively, and the effect of build direction on the cytocompatibility was evaluated. The build direction of 3D printed Co–Cr–Mo alloy changed grain anisotropy; however, there was no statistical difference in grain size. The wettability, protein adsorption, cell attachment, and cell proliferation on the disks of vertical and horizontal products were similar to those on cast alloy; they were significantly lower than those of commercially pure titanium and tissue culture polystyrene. The build direction of 3D printed Co–Cr–Mo alloy does not affect osteoblast compatibility.