Measurement of tryptophan, kynurenine and neopterin in women with and without postpartum blues
Measurement of tryptophan, kynurenine and neopterin in women with and without postpartum blues
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DOI：
10.1016/j.jad.2004.12.013
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发表时间：
2005-06-01
影响因子：
6.6
通讯作者：
Sperner-Unterweger, B
中科院分区：
文献类型：
--
作者：
Kohl, C;Walch, T;Sperner-Unterweger, B
背景：色氨酸降解酶吲哚胺 (2,3)-双加氧酶的激活被证明在耐受诱导中至关重要，以防止胎儿排斥。我们的研究旨在检查产后色氨酸及其分解代谢产物犬尿氨酸的变化，并将它们与作为免疫标记物的新蝶呤进行比较。方法：95 名健康分娩且无并发症的妇女在分娩期间以及出生后 2 天和 4 天提供血液。分析血样中色氨酸、犬尿氨酸和新蝶呤的浓度。女性被要求在第 2 天和第 4 天进行爱丁堡产后抑郁量表 (EPDS)。 结果：在没有忧郁症状的女性 (n=86) 中，色氨酸浓度在出生后 2 天内增加，而在有产后忧郁症状的女性 (n=9; 9.5%) 中，色氨酸浓度没有变化。组间差异达到统计学显着性（p < 0.05）。犬尿氨酸与色氨酸比率 (kyn/trp)（用于估计色氨酸降解程度）的变化在第 0 天和第 2 天时两组之间也存在差异 (p < 0.05)。新蝶呤浓度在第 2 天和第 4 天之间下降（p < 0.05），但两组之间没有差异。局限性：我们的研究人群产后忧郁症状的患病率较低。结论：产后情绪低落与产后血清色氨酸持续较低有关，这是由于基曲氨酸降解增加所致，但与新蝶呤的产后病程无关。 (c) 2005 Elsevier B.V. 保留所有权利。
Background: Activation of the tryptophan-degrading enzyme indoleamine (2,3)-dioxygenase was demonstrated to be critically involved in tolerance induction to prevent fetal rejection.Our study was designed to examine alterations of tryptophan and its catabolic product kynurenine in the postpartum period and to compare them to neopterin as an immunological marker.Methods: 95 healthy women delivering without complications provided blood during labour, and 2 and 4 days after birth. The blood samples were analysed for concentrations of tryptophan, kynurenine and neopterin. Women were asked to perform the Edinburgh Postnatal Depression Scale (EPDS) on days 2 and 4.Results: In women without blues symptoms (n=86) tryptophan concentrations increased within 2 days after birth, whereas they did not change in women with postpartum blues (n=9; 9.5%). The group difference reached statistical significance (p < 0.05). The change of the kynurenine to tryptophan ratio (kyn/trp), which estimates the degree of tryptophan degradation, was also different between the two groups at days 0 and 2 (p < 0.05). Neopterin concentrations decreased between days 2 and 4 (p < 0.05), but there were no differences between the two groups.Limitations: Our study population had a low prevalence of postpartum blues symptoms.Conclusion: Low postpartal mood is associated with continuously low serum tryptophan after delivery due to an increased degradation to kyrturenine, but is independent of the postpartal course of neopterin. (c) 2005 Elsevier B.V. All rights reserved.