Prolonged depression of spinal transmission of nociceptive information by 5-HT administered in the substantia gelatinosa: antagonism by methysergide
Prolonged depression of spinal transmission of nociceptive information by 5-HT administered in the substantia gelatinosa: antagonism by methysergide
复制标题
凝胶质中给予 5-HT 的伤害性信息的脊髓传输的长期抑制：美西麦角的拮抗作用
DOI：
10.1016/0006-8993(80)90511-9
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发表时间：
1980
期刊：
影响因子：
2.9
通讯作者：
A. Duggan
中科院分区：
文献类型：
--
作者：
B. T. Griersmith;A. Duggan
有间接证据表明，5-羟色胺(5-HT)可能是由下行纤维释放的一种递质，控制脊髓伤害性信息的传递。因此，电刺激脑干F6核内含5-羟色胺的神经元附近，既产生行为镇痛，又抑制由皮肤伤害性刺激2、5、~AI、16、1S、19、24-26、2S、29兴奋的背角神经元。在先前的研究中，在胶状质(SG)注射5-羟色胺(5-HT)和去甲肾上腺素(NA)，相对选择性地减少了伤害性皮肤刺激对IV和V层神经元的兴奋。这些细胞对头发偏转的反应受到的影响很小。这种对SG受体的影响可能与刺激RAP6核团产生的镇痛作用有关。鞘内注射5-羟色胺对大鼠腰髓产生行为镇痛作用，这种作用可被亚甲基丝氨酸A2逆转。然而，没有证据表明阻断5-羟色胺对背角神经元的作用的物质也能减轻刺激脑干神经元对这些细胞的抑制。事实上，事实证明，很难找到合适和可靠的5-羟色胺对单个中枢神经元影响的拮抗剂。5-羟色胺对外周组织的作用的拮抗剂，当在中枢神经元胞体附近注射时，被报道不能减少5-HT1，9，~，2a的作用或部分拮抗5-HT1，4，6-S，a0，31的作用。在本实验中，我们观察了甲基丝氨酸和麦角酸二乙胺(LSD)对5-羟色胺作用的拮抗作用。
There is indirect evidence that 5-hydroxytryptamine (5-HT) may be a transmitter released by descending fibres which control the spinal transmission of nociceptive information. Thus, electrical stimulation near 5-HT-containing neurones in the raph6 nuclei of the brain stem produces both behavioural analgesia and inhibition of dorsal horn neurones excited by cutaneous noxious stimuli 2, 5,~ AI, 16, 1s, 19, 24-26, 2s, 29. In a previous study 21, 5-HT and noradrenaline (NA), administered in the substantia gelatinosa (SG), relatively selectively reduced the excitation of neurones of laminae IV and V by noxious skin stimuli. Responses of these cells to hair deflection were minimally affected. This effect at receptors in the SG could be relevant to analgesia produced by stimulation of raph6 nuclei. Intrathecal administration of 5-HT to the lumbar cord of the rat produced behavioural analgesia which was reversed by methysergide a2.It has not been shown, however, that a substance which blocks the action of 5-HT on dorsal horn neurones also reduces the inhibition of these cells by brain stem raph6 stimulation. Indeed, it has proved difficult to obtain a suitable and reliable antagonist of the effects of 5-HT on single central neurones. Antagonists of the effects of 5-HT on peripheral tissues, when ejected electrophoretically near cell bodies of central neurones have been reported not to reduce the effects of 5-HT 1, 9,~, 2a or to partially antagonize 5-HT effectsS, 4, 6-s, a0, 31. In the present experiments methysergide and lysergic acid diethylamide (LSD), were examined for possible antagonism of the action of 5-HT administered in the SG.