Novel contrast media based on the liquid metal gallium for in vivo digestive tract radiography: a feasibility study
Novel contrast media based on the liquid metal gallium for in vivo digestive tract radiography: a feasibility study
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用于体内消化道放射线照相的基于液态金属镓的新型造影剂：可行性研究
DOI：
10.1007/s10534-019-00212-5
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发表时间：
2019
期刊：
影响因子：
3.5
通讯作者：
Liu Jing
中科院分区：
文献类型：
--
作者：
Liu Huan;Yu Yang;Wang Wei;Liu Ying;An Yonghui;Wang Qian;Liu Jing
硫酸钡作为造影剂在胃肠道造影和疾病诊断中发挥着重要作用。但由于其成像效果的限制和其他成像技术的进步，其应用逐渐减少。本文首次将液态金属镓作为一种改进的造影剂应用于小鼠在体消化道造影。在CT扫描下，镓直观地产生了良好的对比效果。根据出院时间、器官组织切片、存活状态和体重的记录，证明液态金属用于胃肠造影是可行和安全的。此外，已经测试了镓和硫酸钡的混合物，其在对比度和细节方面都显示出更好的性能。因此，镓及其与硫酸钡的混合物具有良好的成像对比效果和可接受的安全性，可能在动物实验中作为消化道造影剂的潜在候选物，甚至可能作为临床使用的替代造影剂。
The barium sulfate has been playing an important role as the contrast medium in gastrointestinal radiography and disease diagnosis. However, its application has been gradually reduced due to the limitation of its imaging effect and the progress of other imaging techniques. Here, the liquid metal gallium was proposed as an improved contrast agent, which was applied in the in vivo digestive tract radiography of the mice for the first time. Under the CT scanning, the gallium produced excellent contrast effect intuitively. According to the records of discharge time, the tissue sections of organs, the survival state and body weight, the liquid metal was proven to be capable and safe for gastrointestinal radiography. Further, the mixture of the gallium and the barium sulfate has been tested, which showed better performance in both contrast and detail. Therefore, with the characteristics of better imaging contrast effect and acceptable safety, the gallium and its mixture with the barium sulfate might be useful as potential candidates for digestive tract contrast agent in animal experiments, even possibly as alternative contrast agents for clinical use.