Constraints on Fluctuations in Sparsely Characterized Biological Systems.
Constraints on Fluctuations in Sparsely Characterized Biological Systems.
复制标题
DOI：
10.1103/physrevlett.116.058101
复制
发表时间：
2016-02-05
影响因子：
8.6
通讯作者：
Paulsson J
中科院分区：
文献类型：
--
作者：
Hilfinger A;Norman TM;Vinnicombe G;Paulsson J
生化过程本质上是随机的，在其他相同的细胞中产生分子波动。这种“噪声”是普遍存在的，但已被证明难以分析，因为大多数系统是稀疏的特点，在单细胞水平，因为非线性随机模型是分析棘手的。在这里，我们完全相关的平均丰度，寿命，步长和协方差的任何一对组件在复杂的随机反应系统，即使当其他组件的动态是未指定的。使用基本的数学不等式，然后我们建立整个类的系统的界限。这些界限突出了基本的权衡，表明如何有效的组装过程必须始终表现出大的波动，在亚基水平和消除波动，在一个细胞成分需要创造异质性在另一个。
Biochemical processes are inherently stochastic, creating molecular fluctuations in otherwise identical cells. Such “noise” is widespread but has proven difficult to analyze because most systems are sparsely characterized at the single cell level and because nonlinear stochastic models are analytically intractable. Here, we exactly relate average abundances, lifetimes, step sizes, and covariances for any pair of components in complex stochastic reaction systems even when the dynamics of other components are left unspecified. Using basic mathematical inequalities, we then establish bounds for whole classes of systems. These bounds highlight fundamental trade-offs that show how efficient assembly processes must invariably exhibit large fluctuations in subunit levels and how eliminating fluctuations in one cellular component requires creating heterogeneity in another.