Inbred strain variation in contextual and cued fear conditioning behavior
Inbred strain variation in contextual and cued fear conditioning behavior
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DOI：
10.1007/s003350020039
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发表时间：
2001-08-01
期刊：
影响因子：
2.5
通讯作者：
Flaherty, L
中科院分区：
文献类型：
--
作者：
Bolivar, VJ;Pooler, O;Flaherty, L
一些常用的近交系在一个自动化的计算机控制系统中进行了恐惧条件反射的研究。对照研究被用来验证自动化系统。对休克的反应也被监测，以确定它是否与背景和/或暗示的条件反射行为有关。给129S1/SvImJ(129只)、A/J(A)、BALB/cByJ(BALB)、C3H/HeJ(C3H)、C57BL/6J(B6)、CBA/J(CBA)、DBA/2J(D2)和FVB/NJ(FVB)的雄性和雌性小鼠分别进行3次纯音刺激后，24 h后测定恐惧条件反射。两种菌株对酸性的反应均有显著差异。为了确定视觉对这一行为的影响，将C3H小鼠(有视网膜变性)与C3.BLiA-+(Pdc6b)同源基因(无视网膜变性)进行了比较。在这里，视觉被发现在这个范式中对反应的作用是最小的。因为这种恐惧条件反射测试是自动化的，它可以用于快速筛选大量的II类小鼠，如所需的毛皮突变研究。
A number of commonly used inbred strains were surveyed in a fear-conditioning paradigm conducted with an automated computer-controlled system. Control studies were used to verify the automated system. Response to shock was also monitored to determine if it was associated with contextual and/or cued conditioning behavior. After three pairings of tone with shock, fear conditioning was measured 24 h later in 129S1/SvImJ (129), A/J (A), BALB/cByJ (BALB), C3H/HeJ (C3H), C57BL/6J (B6), CBA/J (CBA), DBA/2J (D2), and FVB/NJ (FVB) male and female mice. There were both significant strain acid sex differences in response. To determine the effects of vision on this behavior, C3H mice (with retinal degeneration) were compared with C3.BLiA-+(Pdc6b) congenics (withoul retinal degeneration). Here, vision was Found to pl:ly a minimal role in responsiveness in this paradigm. Because this fear-conditioning test is;automated, it can be used for the rapid screening of ii large number of mice, such as required fur mutagenesis studies.