Variations in the PDCD6 gene are associated with increased uterine leiomyoma risk in the Chinese.
Variations in the PDCD6 gene are associated with increased uterine leiomyoma risk in the Chinese.
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DOI：
10.1089/gtmb.2012.0461
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发表时间：
2013-07
影响因子：
1.4
通讯作者：
Kui Zhang;Bin Zhou;Shaoqing Shi;Yaping Song;Lin Zhang
中科院分区：
文献类型：
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作者：
Kui Zhang;Bin Zhou;Shaoqing Shi;Yaping Song;Lin Zhang
细胞程序性死亡6(PDCD6)参与T细胞受体、Fas和糖皮质激素诱导的细胞程序性死亡。为探讨PDCD6基因多态性与子宫肌瘤(UL)发病风险的关系，采用病例对照研究方法，研究了PDCD6基因两个单核苷酸多态(rs4957014和rs3756712)与绝经前子宫肌瘤(UL)风险的关系。采用聚合酶链式反应-限制性片段长度多态性分析方法检测两个SNPs的基因分型。Rs4957014的T等位基因和rs3756712的T等位基因显著增加UL的危险性(rs4957014的P=0.016，优势比[OR]=1.325，95%可信区间[CI]=1.053~1.668；rs3756712的P<；0.0001，OR=1.898，95%CI=1.457~2.474)。在不同的遗传模型中，UL风险的增加与他们相关。本研究提供了rs4957014和rs3756712与UL风险相关的证据，提示PDCD6基因多态性可能参与UL的发生发展。
Programmed cell death 6 (PDCD6) participates in T cell receptor, Fas, and glucocorticoid-induced programmed cell death. To test the relationship between PDCD6 polymorphisms and uterine leiomyomas (UL) risk, we investigated the association of two SNPs (rs4957014 and rs3756712) in PDCD6 with UL risk in a case-control study of 295 unrelated premenopausal UL patients and 436 healthy postmenopausal control subjects in a population of China. Genotypes of the two SNPs were determined with the use of PCR-restriction fragment length polymorphism assay. Significantly increased UL risks were found to be associated with the T allele of rs4957014 and the T allele of rs3756712 (p=0.016, odds ratio [OR]=1.325, 95% confidence intervals [CI]=1.053-1.668 for rs4957014; p<0.0001, OR=1.898, 95% CI=1.457-2.474 for rs3756712, respectively). Increased UL risks were associated with them in different genetic models. The present study provided evidence that rs4957014 and rs3756712 are associated with UL risk, the results indicated that genetic polymorphisms in PDCD6 may contribute to the development of UL.