Abnormal metabolic network activity in Parkinson's disease: test-retest reproducibility
Abnormal metabolic network activity in Parkinson's disease: test-retest reproducibility
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DOI：
10.1038/sj.jcbfm.9600358
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发表时间：
2007-03-01
影响因子：
6.3
通讯作者：
Eidelberg, David
中科院分区：
文献类型：
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作者：
Ma, Yilong;Tang, Chengke;Eidelberg, David
帕金森病 (PD) 与局部脑功能异常模式有关。这种 PD 相关协方差模式 (PDRP) 的表达已用于评估疾病进展和治疗反应。在本研究中，我们通过前瞻性计算 PD 患者和健康志愿者的 O-15-水 ((H2O)-O-15) 和 F-18- 氟脱氧葡萄糖 (FDG) 正电子发射断层扫描 (PET) 扫描中的 PDRP 网络表达（PDRP 评分），验证了 PDRP 网络作为帕金森症的衡量标准。该措施的可靠性也在受试者中进行了评估，使用测试-再测试设计，对轻度受影响和晚期 PD 患者进行基线扫描和左旋多巴或深部脑刺激 (DBS) 治疗期间的扫描。在对 (H2O)-O-15 或 FDG PET 获得的脑部扫描进行前瞻性分析时，我们发现 PD 患者的 PDRP 表达相对于对照组显着升高 (P < 0.001)。使用两种示踪剂扫描的 PD 受试者中，根据 (H2O)-O-15 计算的 PDRP 评分与 FDG 图像之间存在显着相关性（R-2 = 0.61；P < 0.001）。对于 PET 会话内和相隔长达 2 个月的会话之间测量的 PDRP 分数，测试 - 重测的重现性非常高（组内相关系数 (ICC) > 0.92）。在基线和治疗期间扫描的早期和晚期 PD 患者中观察到这种高再现性。对于未用药和治疗的情况，该测量的受试者内变异性均小于 10%。这些发现表明 PDRP 网络是帕金森病区域功能异常的可重复且稳定的描述符。 PD 患者中 PDRP 表达的量化可以作为该疾病的 PET 干预研究中的潜在生物标志物。
Parkinson's disease ( PD) is associated with an abnormal pattern of regional brain function. The expression of this PD- related covariance pattern ( PDRP) has been used to assess disease progression and the response to treatment. In this study, we validated the PDRP network as a measure of parkinsonism by prospectively computing its expression ( PDRP scores) in O-15- water ((H2O)-O-15) and F-18- fluorodeoxyglucose ( FDG) positron emission tomography ( PET) scans from PD patients and healthy volunteers. The reliability of this measure was also assessed within subjects using a test - retest design in mildly affected and advanced PD patients scanned at baseline and during treatment with levodopa or deep brain stimulation ( DBS). We found that PDRP expression was significantly elevated in PD patients ( P < 0.001) relative to controls in a prospective analysis of brain scans obtained with either (H2O)-O-15 or FDG PET. A significant correlation ( R-2 = 0.61; P < 0.001) was evident between PDRP scores computed from (H2O)-O-15 and FDG images in PD subjects scanned with both tracers. Test - retest reproducibility was very high ( intraclass correlation coefficient ( ICC) > 0.92) for PDRP scores measured both within PET session and between sessions separated by up to 2 months. This high reproducibility was observed in both early stage and advanced PD patients scanned at baseline and during treatment. The within- subject variability of this measure was less than 10% for both unmedicated and treated conditions. These findings suggest that the PDRP network is a reproducible and stable descriptor of regional functional abnormalities in parkinsonism. The quantification of PDRP expression in PD patients can serve as a potential biomarker in PET intervention studies for this disorder.