Case-control studies on risk factors for chronic obstructive pulmonary disease: how does the sampling of the cases and controls affect the results?
Case-control studies on risk factors for chronic obstructive pulmonary disease: how does the sampling of the cases and controls affect the results?
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DOI：
10.1111/j.1752-699x.2009.00154.x
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发表时间：
2010-04-01
影响因子：
1.7
通讯作者：
Bakke, Per Sigvald
中科院分区：
文献类型：
--
作者：
Sorheim, Inga-Cecilie;Johannessen, Ane;Bakke, Per Sigvald
引言：抽样被认为是至关重要的病例对照研究的有效性。理想情况下，病例和对照组应选择从同一来源的人口，但偏离这种approaches.Objective：我们的目的是研究如何在一项研究中的慢性阻塞性肺疾病（COPD）的发病率-疾病的关系受到影响的抽样来源的病例和controls.Methods：挪威的病例对照研究包括1909名受试者使用三个来源的招募病例（一般人群，医院登记和志愿者）和两个来源的控制（一般人群和志愿者）。这导致病例和对照的六个采样组合（组A-F）。我们研究了性别、年龄、吸烟、文化程度和合并症的危险因素与COPD在这六个抽样groups.Results：几个疾病的关联依赖于抽样来源的变化，从而证明选择偏倚的可能性。理论上最理想的抽样组可能是A组，其中病例组和对照组都是从普通人群中招募的。当使用A组作为参考，组包含自愿控制和/或医院为基础的情况下偏离最高，这表明更高的敏感性选择偏差在这些groups.Conclusion：招聘从几个来源，我们的研究设计容易受到选择偏差。我们的研究结果应提高对抽样过程的认识，并鼓励在未来的研究中从同一来源人群中抽样病例和对照。COPD危险因素的病例对照研究：病例和对照的抽样如何影响结果？临床呼吸杂志2010; 4：89-96。
Introduction:Sampling is regarded as crucial to the validity of case-control studies. Ideally, cases and controls should be selected from the same source population, but deviations from this approach are often seen.Objective:Our objective was to examine how exposure-disease relationships in a study on chronic obstructive pulmonary disease (COPD) were affected by the sampling sources of cases and controls.Methods:A Norwegian case-control study on COPD including 1909 subjects used three sources of recruitment for cases (general population, hospital registry and volunteers) and two sources for controls (general population and volunteers). This resulted in six sampling combinations of cases and controls (groups A-F). We examined how the risk factors gender, age, smoking, educational level and comorbidity were associated with COPD in these six sampling groups.Results:Several exposure-disease associations were dependent on variation in sampling source, thereby demonstrating the possibility of selection bias. The theoretically most ideal sampling group is likely group A, where both cases and controls are recruited from a general population. When using group A as a reference, the groups containing either voluntary controls and/or hospital-based cases deviated the most, suggesting higher susceptibility to selection bias in these groups.Conclusion:Recruitment from several sources made our study design vulnerable to selection bias. Our findings should bring about increased awareness to the sampling process, and encourage sampling of cases and controls from the same source population in future studies.Please cite this paper as: S circle divide rheim I-C, Johannessen A, Grydeland TB, Omenaas ER, Gulsvik A and Bakke PS. Case-control studies on risk factors for COPD: how does the sampling of the cases and controls affect the results? The Clinical Respiratory Journal 2010; 4: 89-96.