The role of chemokines in inflammatory joint disease
The role of chemokines in inflammatory joint disease
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DOI：
10.1002/jlb.59.1.6
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发表时间：
1996-01-01
影响因子：
5.5
通讯作者：
Strieter, RM
中科院分区：
文献类型：
--
作者：
Kunkel, SL;Lukacs, N;Strieter, RM
类风湿性关节炎（RA）是一种自身免疫性疾病，其特征是滑膜间隙和关节组织内大量白细胞群的激发和激活，募集的白细胞随后在滑膜细胞增殖、血管翳形成和骨侵蚀中发挥重要作用。特定细胞因子（包括趋化因子）与活动性关节炎的关联，但细胞因子表达的纵向分析和这些介质的因果作用尚未确定。动物模型和细胞培养系统已被证明可用于识别慢性关节炎症维持期间各种细胞因子的表达。此外，动物模型提供了有关特定介质对实验性关节炎发展的动力学产生和贡献的重要信息。这些研究提供了对白细胞参与炎症性关节疾病的潜在机制的深入了解。
Rheumatoid arthritis (RA) is an autoimmune disease characterized by the elicitation and activation of a number of leukocyte populations within both the synovial space and joint tissue, The recruited leukocytes subsequently play an instrumental role in synovial cell proliferation, pannus formation, and bone erosion, Although it is known that leukocytes are important participants in the evolving joint pathology, the mechanism responsible for the successful elicitation of cells to the joint is not clear, A number of studies have identified an association of specific cytokines, including chemokines, with active arthritis, but longitudinal analyses of cytokine expression and the causal role of these mediators have not been defined, Animal models and cell culture systems have proved useful in identifying the expression of various cytokines during the maintenance of chronic joint inflammation, In addition, animal models have provided important information regarding the kinetic production and contribution of specific mediators to the development of experimental arthritis, These studies provide insight into the potential mechanisms for leukocyte involvement in inflammatory joint disease.