Protooncogene abnormalities in colon cancers and adenomatous polyps.
Protooncogene abnormalities in colon cancers and adenomatous polyps.
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结肠癌和腺瘤性息肉中的原癌基因异常。
DOI：
10.1016/s0016-5085(87)91074-2
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发表时间：
1987
期刊：
影响因子：
29.4
通讯作者：
Cline,MJ
中科院分区：
文献类型：
--
作者：
Meltzer,SJ;Ahnen,DJ;Battifora,H;Yokota,J;Cline,MJ
为探讨大肠癌癌基因异常的发生率及其临床意义，用14种不同的原癌基因探针对45例大肠癌和15例大肠良性腺瘤的脱氧核糖核酸进行了杂交。在切除时，22%的癌症中发现了癌基因的缺失。c-myc或c-erbB-2扩增和c-ras-Ha或c-myb等位基因缺失是最常见的异常。癌基因改变的存在与Dukes分期、肿瘤进展或切除后患者生存率无关。一个腺瘤有c-myb癌基因的等位基因缺失，这在正常结肠或邻近癌中均未发现。这些数据表明，谱改变原癌基因在结肠癌是类似的其他腺癌，不稳定的癌基因可以发现之前，明显的恶性发展。
To determine the frequency and clinical significance of oncogene abnormalities in colon cancer, deoxyribonucleic acids trom 45 colon carcinomas and 15 benign adenomas were hybridized with 14 different proto oncogene probes. Abnormalities of oncogenes were found in 22% of cancers at the time of resection. Amplification of c-myc or c-erbB-2 and allelic deletion of c-ras-Ha or c-myb were the most frequent abnormalities. The presence of altered oncogenes did not correlate with Dukes' stage, tumor progression, or patient survival after resection. One adenoma had an allelic deletion of the c-myb oncogene which was not seen in either the normal colon or an adjacent carcinoma. These data indicate that the spectrum of altered proto oncogenes in colon carcinoma is similar to that of other adenocarcinomas, and that unstable oncogenes can be found before overt malignancy develops.