Role of the PE/PPE Family in Host-Pathogen Interactions and Prospects for Anti-Tuberculosis Vaccine and Diagnostic Tool Design.
Role of the PE/PPE Family in Host-Pathogen Interactions and Prospects for Anti-Tuberculosis Vaccine and Diagnostic Tool Design.
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PE/PPE 家族在宿主与病原体相互作用中的作用以及抗结核疫苗和诊断工具设计的前景
DOI：
10.3389/fcimb.2020.594288
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发表时间：
2020
影响因子：
5.7
通讯作者：
Zhang X
中科院分区：
文献类型：
--
作者：
Qian J;Chen R;Wang H;Zhang X
pe/ppe基因存在于致病性、生长缓慢的结核分枝杆菌和其他分枝杆菌中。结核复合菌（MTBC）。这些基因被认为是宿主-病原体相互作用的关键因素。虽然大多数PE/PPE家族蛋白的功能尚不清楚，但越来越多的证据表明该家族与M.肺结核感染。在这里，我们审查PE/PPE蛋白，这被认为是链接到ESX系统功能的作用。此外，我们强调了PE/PPE蛋白的功能，包括它们在宿主细胞相互作用，免疫反应调节和细胞命运决定在复杂的宿主-病原体过程中的作用。最后，我们提出了PE/PPE蛋白研究的未来方向，并考虑如何将目前的知识应用于设计更具体的诊断和有效的疫苗，用于全球结核病控制。
The pe/ppe genes are found in pathogenic, slow-growing Mycobacterium tuberculosis and other M. tuberculosis complex (MTBC) species. These genes are considered key factors in host-pathogen interactions. Although the function of most PE/PPE family proteins remains unclear, accumulating evidence suggests that this family is involved in M. tuberculosis infection. Here, we review the role of PE/PPE proteins, which are believed to be linked to the ESX system function. Further, we highlight the reported functions of PE/PPE proteins, including their roles in host cell interaction, immune response regulation, and cell fate determination during complex host-pathogen processes. Finally, we propose future directions for PE/PPE protein research and consider how the current knowledge might be applied to design more specific diagnostics and effective vaccines for global tuberculosis control.