Protective Effects of BDNF against C-Reactive Protein-Induced Inflammation in Women.
Protective Effects of BDNF against C-Reactive Protein-Induced Inflammation in Women.
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DOI：
10.1155/2015/516783
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发表时间：
2015
影响因子：
4.6
通讯作者：
Evans MK
中科院分区：
文献类型：
--
作者：
Noren Hooten N;Ejiogu N;Zonderman AB;Evans MK
Background. Since high sensitivity C-reactive protein (hsCRP) is predictive of cardiovascular events, it is important to examine the relationship between hsCRP and other inflammatory and oxidative stress markers linked to cardiovascular disease (CVD) etiology. Previously, we reported that hsCRP induces the oxidative stress adduct 8-oxo-7,8-dihydro-2′deoxyguanosine (8-oxodG) and that these markers are significantly associated in women. Recent data indicates that brain-derived neurotrophic factor (BDNF) may have a role in CVD. Methods and Results. We examined BDNF levels in 3 groups of women that were age- and race-matched with low (<3 mg/L), mid (>3–20 mg/L), and high (>20 mg/L) hsCRP (n = 39 per group) and found a significant association between hsCRP, BDNF, and 8-oxodG. In African American females with high hsCRP, increases in BDNF were associated with decreased serum 8-oxodG. This was not the case in white women where high hsCRP was associated with high levels of BDNF and high levels of 8-oxodG. BDNF treatment of cells reduced CRP levels and inhibited CRP-induced DNA damage. Conclusion. We discovered an important relationship between hsCRP, 8-oxodG, and BDNF in women at hsCRP levels >3 mg/L. These data suggest that BDNF may have a protective role in counteracting the inflammatory effects of hsCRP.
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DOI：
10.1161/atvbaha.112.300276
发表时间：
2012-11
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Noren Hooten N;Ejiogu N;Zonderman AB;Evans MK
通讯作者：
Evans MK
影响因子：
37.8
作者：
Pearson, TA;Mensah, GA;Vinicor, F
通讯作者：
Vinicor, F
影响因子：
15.9
作者：
Kermani, P;Rafii, D;Hempstead, BL
通讯作者：
Hempstead, BL
影响因子：
1.8
作者：
Morrell, CH;Pearson, JD;Brant, LJ
通讯作者：
Brant, LJ
影响因子：
10.8
作者：
Prigent-Tessier, Anne;Quirie, Aurore;Demougeot, Celine
通讯作者：
Demougeot, Celine