BIOMECHANICS OF HYDROCEPHALUS - A NEW THEORETICAL-MODEL
BIOMECHANICS OF HYDROCEPHALUS - A NEW THEORETICAL-MODEL
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DOI：
10.1227/00006123-198712000-00019
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发表时间：
1987-12-01
期刊：
影响因子：
4.8
通讯作者：
SEGUCHI, Y
中科院分区：
文献类型：
--
作者：
NAGASHIMA, T;TAMAKI, N;SEGUCHI, Y
有限元法是一种先进的计算机模拟方法，用于脑积水的生物力学研究。本文应用描述含粘性流体多孔介质力学行为的Biot固结理论来描述脑积水脑内组织与流体的耦合行为。用有限元法对脑积水过程进行了计算机模拟，以评价数学模型。使用水平计算机断层扫描（CT）脑切片构建二维有限元模型。根据脑实质的材料特性、载荷特性和边界条件，计算并图示了脑组织间质压力的变化、脑内应力分布和脑室构型。计算机模拟的结果与脑积水患者的CT和磁共振成像的结果进行了比较。该数学模型较好地反映了脑室周围脑脊液水肿和脑室扩大的过程。该模型表明，脑组织中的应力集中和脑实质导水率的增加在脑室周围脑脊液水肿的产生中起重要作用。
The finite element medthod (FEM), an advanced method of computer simulation, is used to examine biomechanical studies of hydrocephalus. Biot''s theory of consolidation, which describes the mechanical behaviorof a porous medium containing viscous fluid, is applied to represent the couple behavior of tissue and fluid in the hydrocephalic brain. A computer simulation of the hydrocephalic process is carried out by FEM to evaluate the mathematical model. A two-dimensional finite element model is constructed using a horizontal computed tomographic (CT) slice of the brain. Specifying the material properties of the brain parenchyma, the loading characteristics, and the boundary conditions, the change of interstitial pressure, intracerebral stress distribution, and ventricular configuration are computed and graphically represented. The results of the computer simulation are compared with the findings of CT and magnetic resonance imaging of hydrocephalic patients. The progress of periventricular cerebrospinal fluid edema and ventricular enlargement is well represented by the mathematical model. The model demonstrated that stress concentration in the brain tissue and increased parenchymal hydraulic conductivity play an important role in the generation of periventricular cerebrospinal fluid edema.