Understanding alcohol use disorders with neuroelectrophysiology.
Understanding alcohol use disorders with neuroelectrophysiology.
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DOI：
10.1016/b978-0-444-62619-6.00023-9
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发表时间：
2014
影响因子：
--
通讯作者：
Porjesz, Bernice
中科院分区：
文献类型：
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作者：
Rangaswamy, Madhavi;Porjesz, Bernice
与各种脑区和神经回路（特别是涉及额叶）的损伤相关的神经认知缺陷与慢性酒精中毒以及发展酒精使用和相关疾病（AUD）的倾向有关。AUD是一种多因素疾病，由行为，遗传和环境负债之间的复杂相互作用引起。神经电生理技术有助于理解大脑和行为的关系，也被证明是非常有用的，在评估遗传素质的酗酒。本章描述了神经电生理测量（脑电图，事件相关电位和事件相关振荡）的结果，这些测量与酒精对大脑的急性和慢性影响有关，以及反映与发展AUD和相关疾病的倾向相关的潜在缺陷的测量结果。这些措施的效用作为有效的内表型，以确定和理解与脑电生理学，认知网络，和AUDs相关的基因也进行了讨论。
Neurocognitive deficits associated with impairments in various brain regions and neural circuitries, particularly involving frontal lobes, have been associated with chronic alcoholism, as well as with a predisposition to develop alcohol use and related disorders (AUDs). AUD is a multifactorial disorder caused by complex interactions between behavioral, genetic, and environmental liabilities. Neuroelectrophysiological techniques are instrumental in understanding brain and behavior relationships and have also proved very useful in evaluating the genetic diathesis of alcoholism. This chapter describes findings from neuroelectrophysiological measures (electroencephalogram, event-related potentials, and event-related oscillations) related to acute and chronic effects of alcohol on the brain and those that reflect underlying deficits related to a predisposition to develop AUDs and related disorders. The utility of these measures as effective endophenotypes to identify and understand genes associated with brain electrophysiology, cognitive networks, and AUDs has also been discussed.