Interleukin-37 expression and its potential role in oral leukoplakia and oral squamous cell carcinoma.
Interleukin-37 expression and its potential role in oral leukoplakia and oral squamous cell carcinoma.
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IL-37在口腔白斑和口腔鳞状细胞癌中的表达及其潜在作用
DOI：
10.1038/srep26757
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发表时间：
2016-05-26
影响因子：
4.6
通讯作者：
Chen Q
中科院分区：
文献类型：
--
作者：
Lin L;Wang J;Liu D;Liu S;Xu H;Ji N;Zhou M;Zeng X;Zhang D;Li J;Chen Q
据报道，白细胞介素 37 (IL-37) 在先天免疫反应中发挥着重要作用，并与多种癌症有关。然而，IL-37 与口腔粘膜癌发生之间关联的研究尚未明确。该研究的目的是评估 IL-37 的表达并探讨其在口腔粘膜癌发生中的作用。 IL-37的表达从正常对照（NC）到口腔白斑（OLK）和口腔鳞状细胞癌（OSCC）增加。此外，有和没有轻度/中度不典型增生的 OLK 评分之间存在统计学上的显着差异（P<0.001）。此外，有淋巴结转移的OSCC中IL-37的表达低于无转移的OSCC（P<0.01）。此外，RAW264.7细胞中IL-37的过度表达显着减少了伪足、空泡化以及IL-6、TNF-α和IL-1β的表达。最后，我们发现IL-37及其受体IL-18Rα而非其结合伙伴IL-18BP在口腔粘膜癌变的不同阶段具有相似的组织定位和表达趋势。总体而言，IL-37可作为早期口腔肿瘤发生和癌前病变恶变风险评估的生物标志物。
Interleukin 37 (IL-37) has been reported to play a significant role in innate immune response and to be involved in several kinds of cancers. However, the investigation of association between IL-37 and oral mucosa carcinogenesis hasn't been clearly established. The aim of the study was to assess IL-37 expression and explore its role in oral mucosa carcinogenesis. The expression of IL-37 increased from normal control (NC) to Oral leukoplakia (OLK) and oral squamous cell carcinoma (OSCC). Moreover, statistically highly significant difference was present between scores of OLK with and without mild/moderate dysplasia (P < 0.001). In addition, IL-37 expression was lower in OSCC with lymph node metastasis than those without metastasis (P < 0.01). What’s more, overexpression of IL-37 in RAW264.7 cells remarkably reduced the pseudopodia, vacuolization and the expression of IL-6, TNF-α, and IL-1β. Finally, we found IL-37 and its receptor IL-18Rα but not its binding partner IL-18BP have similar tissue location and expression trend in different stages of oral mucosa carcinogenesis. Overall, IL-37 can be used as a biomarker for early oral tumorigenesis and for malignant transformation risk assessment of premalignant lesions.