Maternal copper status and neuropsychological development in infants and preschool children
Maternal copper status and neuropsychological development in infants and preschool children
复制标题
DOI：
10.1016/j.ijheh.2019.01.007
复制
发表时间：
2019-04-01
影响因子：
6
通讯作者：
Llop, Sabrina
中科院分区：
文献类型：
--
作者：
Amoros, Ruben;Murcia, Mario;Llop, Sabrina
前言：铜是生物过程中必不可少的元素，然而，过量的铜由于其活动性而可能是有害的。很少有研究评估其潜在的神经毒性作用。本研究旨在评估母体铜水平与儿童神经心理发育之间的关系。方法：研究对象为西班牙INMA(即儿童与环境)项目的母子配对。采用电感耦合等离子体质谱检测妊娠早期(2003-2005年)血清中铜的含量。采用贝利婴儿发育量表(BSID)和麦卡锡儿童能力量表(MSCA)对651例12个月和490例5岁儿童进行神经心理发育评估。在孕期和儿童期通过问卷调查获得协变量。结果：母血铜平均+/-标准差为1606+/-272mUg/L。在多因素分析中，母血铜水平与BSID心理量表(β=-0.051；95%可信区间[CI]-0.102，-0.001)和明尼苏达儿童智力量表(β=-0.044；95%CI：-0.094，0.006)呈负相关。男孩的得分低于女孩，12个月时Cu值增加(心理量表的交互作用p值=0.040，精神运动量表的交互p值=0.074)。这一效应修饰在5岁时消失。在母亲铁浓度最低的儿童中，铜与MSCA评分(言语、知觉表现、整体记忆和运动、一般认知和执行功能量表)呈负相关。结论：本研究中观察到的铜浓度在以往研究中为健康孕妇建立的参考范围内。这项研究的结果有助于为关于怀孕期间铜可能的神经毒性能力的重要信息提供科学知识。
Introduction: Copper (Cu) is an essential element involved in biological processes; however, excessive Cu could be harmful because of its reactive nature. Very few studies have evaluated its potential neurotoxic effects. We aimed to evaluate the association between maternal Cu levels and children's neuropsychological development.Methods: Study subjects were mother-child pairs from the Spanish INMA (i.e. Childhood and Environment) Project. Cu was measured by inductively coupled plasma mass spectrometry in serum samples taken at the first trimester of pregnancy (2003-2005). Neuropsychological development was assessed using the Bayley Scales of Infant Development (BSID) at 12 months (n = 651) and the McCarthy Scales of Children's Abilities (MSCA) at 5 years of age (n = 490). Covariates were obtained by questionnaires during pregnancy and childhood. Multivariate linear and non-linear models were built in order to study the association between maternal Cu and child neuropsychological development.Results: The mean +/- standard deviation of maternal Cu concentrations was 1606 +/- 272 mu g/L. In the multivariate analysis, a negative linear association was found between maternal Cu concentrations and both the BSID mental scale (beta = - 0.051; 95% confidence intervals [CI]: - 0.102, - 0.001) and the MSCA verbal scale (beta = - 0.044; 95%CI:-0.094, 0.006). Boys obtained poorer scores than girls, with increasing Cu at 12 months (interaction p-value = 0.040 for the mental scale and 0.074 for the psychomotor scale). This effect modification disappeared at 5 years of age. The association between Cu and the MSCA scores (verbal, perceptive performance, global memory and motor, general cognitive, and executive function scales) was negative for those children with lowest maternal iron concentrations ( < 938 mu g/L).Conclusion: The Cu concentrations observed in our study were within the reference range established for healthy pregnant women in previous studies. The results of this study contribute to the body of scientific knowledge with important information on the possible neurotoxic capability of Cu during pregnancy.