BDNF Va166Met polymorphism is associated with body mass index in healthy adults
BDNF Va166Met polymorphism is associated with body mass index in healthy adults
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DOI：
10.1159/000093341
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Gordon, E
中科院分区：
文献类型：
--
作者：
Gunstad, J;Chofield, P;Gordon, E
尽管最近的研究表明脑源性神经营养因子 Val66Met 多态性与饮食失调之间可能存在关系，但没有研究检验 Met-Met 基因型与健康个体较低体重指数 (BMI) 相关的可能性。我们在 481 名没有明显病史或精神病史的成年人（年龄范围 18-82 岁）中检查了这种可能性。调整性别后，协方差分析显示，具有 Met-Met 基因型的人的 BMI 低于具有 Val-Met/Val-Val 基因型的人（22.28 +/- 3.77 vs. 24.72 +/- 4.81）。当分别比较所有三种基因型时，出现了类似但不显着的趋势。这些发现表明 Val66Met 多态性与健康成年人的 BMI 之间可能存在关系。需要进一步的工作来阐明这种关系的可能机制。版权所有 Q 2006 S. Karger AG，巴塞尔。
Although recent studies suggest a possible relationship between the brain-derived neurotrophic factor Val66Met polymorphism and eating disorders, no study has examined the possibility that the Met-Met genotype is associated with a lower body mass index (BMI) in healthy individuals. We examined this possibility in 481 adults (age range 18-82 years) without significant medical or psychiatric history. After adjusting for gender, analysis of covariance showed that persons with the Met-Met genotype had a lower BMI than those with the Val-Met/Val-Val genotypes (22.28 +/- 3.77 vs. 24.72 +/- 4.81). A similar, though nonsignificant, trend emerged when comparing all three genotypes separately. These findings suggest a possible relationship between Val66Met polymorphism and BMI in healthy adults. Further work is needed to clarify possible mechanisms for this relationship. Copyright Q 2006 S. Karger AG, Basel.