Inkjet printing for high-throughput cell patterning
Inkjet printing for high-throughput cell patterning
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DOI：
10.1016/j.biomaterials.2003.10.052
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发表时间：
2004-08-01
期刊：
影响因子：
14
通讯作者：
Boland, T
中科院分区：
文献类型：
--
作者：
Roth, EA;Xu, T;Boland, T
喷墨打印技术适用于组织工程和生物材料开发的复杂领域，通过自动化过程实现这种高通量能力，以实现精确控制和重复性，从而有可能促进这些新兴技术的进步。本文提出了一种应用高通量喷墨打印控制细胞附着和增殖的方法，该方法通过精确、自动地沉积胶原蛋白。结果表明，商用喷墨打印是可行的。这项技术可以通过沉积生物活性蛋白质来创建分辨率为350微米的可行细胞图案。这种方法展示了现成的喷墨打印和生物材料的结合，并具有适应组织工程和菌落图案应用的潜力。将这种方法应用到细胞结构的三维结构中，最终使用自下而上的方法进行高通量组织工程是可能的。(C)2003爱思唯尔有限公司。保留所有权利。
The adaptation of inkjet printing technology to the complex fields of tissue engineering and biomaterial development presents the potential to increase progress in these emerging technologies through the implementation of this high-throughput capability via automated processes to enable precise control and repeatability. In this paper, a method of applying high-throughput inkjet printing to control cellular attachment and proliferation by precise, automated deposition of collagen is presented. The results indicate that commercial inkjet printing. technology can be used to create viable cellular patterns with a resolution of 350 mum through the deposition of biologically active proteins. This method demonstrates a combination of off-the-shelf inkjet printing and biomaterials and has potential to be adapted to tissue engineering and colony patterning applications. Adapting this method into the three-dimensional construction of cellular structures for eventual high-throughput tissue engineering using a bottom-up approach is possible. (C) 2003 Elsevier Ltd. All rights reserved.