Radio-frequency tissue ablation of the liver: in vivo and ex vivo experiments with four different systems
Radio-frequency tissue ablation of the liver: in vivo and ex vivo experiments with four different systems
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DOI：
10.1007/s00330-003-1970-0
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发表时间：
2003-10-01
影响因子：
5.9
通讯作者：
Doenz, F
中科院分区：
文献类型：
--
作者：
Denys, AL;De Baere, T;Doenz, F
本研究旨在测试四种不同射频消融（RFA）系统在大型动物正常肝实质中的有效性。根据制造商规范，使用Radionics集束针、RITA starburst XL针、Radiotherapeutics Le Veen 4.0针和Berchtold 14-G盐水灌注15 mm有源尖端针，对活体猪肝和离体小牛肝脏进行RFA。根据垂直直径（Dv）和横向直径（Dt）的测量值计算RF的组织凝固体积。使用Dt/Dv之间的比率表征病变形状。放射治疗和RITA产生的体内病灶体积为42+/-10，39 +/-4 cm（3），具有可再现的球形（Dt/Dv分别为1.01+/-0.16和0.97+/-0.1）。放射线产生的体内RF损伤体积为29+/-11 cm（3），呈卵形（Dt/Dv 0.88+/-0.09）。由于8只动物中有5只在治疗期间死亡，因此无法在体内评估Berchtold器械的射频损伤。每种系统的离体射频损伤体积相似;但是，放射治疗器械产生的形状损伤比其他系统更可再现。在我们的实验研究中，我们发现体内可扩张针系统之间没有差异。冷却的针在体内产生略小的卵圆形病变。
The aim of this study was to test the efficacy of four different radio-frequency ablation (RFA) systems in normal hepatic parenchyma in large animals. The RFA was applied to pig livers in vivo and to calf livers ex vivo using the Radionics cluster needle, RITA starburst XL needle, Radiotherapeutics Le Veen 4.0 needle, and the Berchtold 14-G saline-perfused 15-mm active-tip needle based on constructor specifications. The volume of tissue coagulation from RF was calculated from measurements of the vertical diameter (Dv) and transverse diameter (Dt). Lesion shape was characterized using the ratio between Dt/Dv. Radiotherapeutics and RITA produced in vivo lesion volume of 42+/-10, 39+/-4 cm(3) with a reproducible spherical shape (Dt/Dv of 1.01+/-0.16 and 0.97+/-0.1, respectively). Radionics produced in vivo RF lesions volume of 29+/-11 cm(3) with an ovoid shape (Dt/Dv 0.88+/-0.09). The RF lesions with the Berchtold device could not be assessed in vivo as 5 of 8 animals died during treatment. Ex vivo RF lesions had similar volumes with each system; however, the Radiotherapeutics device produced more reproducible shaped lesions than the other systems. In our experimental study, we found no difference between expandable needle systems in vivo. Cooled needles produced slightly smaller and ovoid shape in vivo lesions.