Pharyngeal pumping rate does not reflect lifespan extension in C. elegans transgenerational longevity mutants.
Pharyngeal pumping rate does not reflect lifespan extension in C. elegans transgenerational longevity mutants.
复制标题
咽泵的速率不能反映秀丽隐杆线虫转世寿命长突变体中的寿命延长。
DOI：
10.17912/micropub.biology.000719
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发表时间：
2023
影响因子：
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通讯作者：
Lee, Teresa Wei-Sy
中科院分区：
文献类型：
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作者：
Croft, Jaime C;Colunga, Arthur;Solh, Lea;Dillon, Michaela K;Lee, Teresa Wei-Sy
表观遗传修饰必须随着每一代的产生而重新编程。在秀丽隐杆线虫中，组蛋白甲基化重编程的缺陷允许跨代获得长寿。例如，假定的H3 K9去甲基化酶JHDM-1的突变在6至10代后延长寿命。我们注意到，长寿的jhdm-1突变体比同代野生型动物更健康。为了量化健康状况，我们比较了具有正常寿命的早期人群和具有长寿命的晚期人群之间特定成年年龄的咽泵率的常见指标。长寿并不影响泵送速率，但长寿的突变体在年轻时停止泵送，这表明可能的能量守恒，以延长寿命。
Epigenetic modifications must be reprogrammed with each new generation. In Caenorhabditis elegans , defects in histone methylation reprogramming allow for the transgenerational acquisition of longevity. For example, mutations in the putative H3K9 demethylase JHDM-1 extend lifespan after six to ten generations. We noticed that long-lived jhdm-1 mutants appear healthier than wild-type animals from the same generation. To quantify health, we compared the common metric of pharyngeal pumping rate at specific adult ages between early-gen populations with normal lifespans and late-gen populations with long lifespans. Longevity did not affect pumping rate, but long-lived mutants stop pumping at a younger age, suggesting a possible conservation of energy to extend lifespan.