Functional retinal imaging using adaptive optics swept-source OCT at 1.6 MHz
Functional retinal imaging using adaptive optics swept-source OCT at 1.6 MHz
复制标题
DOI：
10.1364/optica.6.000300
复制
发表时间：
2019-03-20
期刊：
影响因子：
10.4
通讯作者：
Jonnal, Ravi S.
中科院分区：
文献类型：
--
作者：
Azimipour, Mehdi;Migacz, Justin, V;Jonnal, Ravi S.
光感受器功能的客观光学评估可能允许比当前方法如视野检查、电生理学和临床成像更早地诊断视网膜疾病。在这项工作中，我们描述了一个自适应光学（AO）光学相干断层扫描（OCT）系统，旨在测量功能的单锥细胞对可见光刺激的反应。OCT子系统由光栅扫描傅里叶域锁模激光器和闭环操作的AO系统组成，该激光器以1.64 MHz采集A扫描，中心波长为1063 nm。连续体积图像的分析表明，锥光感受器的相位变化与外段伸长一致，并与刺激强度成比例，以及外段和视网膜色素上皮的其他形态学变化。(C)根据OSA开放获取出版协议的条款，2019年美国光学学会
Objective optical assessment of photoreceptor function may permit earlier diagnosis of retinal disease than current methods such as perimetry, electrophysiology, and clinical imaging. In this work, we describe an adaptive optics (AO) optical coherence tomography (OCT) system designed to measure functional responses of single cones to visible stimuli. The OCT subsystem consisted of a raster-scanning Fourier-domain mode-locked laser that acquires A scans at 1.64 MHz with a center wavelength of 1063 nm and an AO system operating in closed-loop. Analysis of serial volumetric images revealed phase changes of cone photoreceptors consistent with outer segment elongation and proportional to stimulus intensity, as well as other morphological changes in the outer segment and retinal pigment epithelium. (C) 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement