MICE WITH A NULL MUTATION OF THE TGF-ALPHA GENE HAVE ABNORMAL SKIN ARCHITECTURE, WAVY HAIR, AND CURLY WHISKERS AND OFTEN DEVELOP CORNEAL INFLAMMATION
MICE WITH A NULL MUTATION OF THE TGF-ALPHA GENE HAVE ABNORMAL SKIN ARCHITECTURE, WAVY HAIR, AND CURLY WHISKERS AND OFTEN DEVELOP CORNEAL INFLAMMATION
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DOI：
10.1016/0092-8674(93)90227-h
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发表时间：
1993-04-23
期刊：
影响因子：
64.5
通讯作者：
DUNN, AR
中科院分区：
文献类型：
--
作者：
MANN, GB;FOWLER, KJ;DUNN, AR
转化生长因子α（TGF α）基因被破坏的纯合子小鼠是健康和可生育的，尽管一些老年小鼠显示出角膜炎症的证据。与TGF α +/-和+/+动物相比，TGF α-/-小鼠具有明显的皮毛波纹。对TGF α-/-小鼠皮肤的组织学检查揭示了毛囊的显著紊乱。TGF α基因受损的小鼠也有卷曲的胡须，在出生当天首次出现。TGF α-/-小鼠的表型与小鼠突变体wave-l（wa-1）的表型非常相似。TGF α-/-和wa-1小鼠杂交产生的后代显示卷曲须毛表型，表明wa-1表型的基础是TGF α基因的突变。这些观察结果表明，TGF α在决定皮肤结构和调节毛发发育中起着关键作用。
Mice homozygous fora disrupted transforming growth factor alpha (TGFalpha) gene are healthy and fertile, although some older mice show evidence of corneal inflammation. In contrast with TGFalpha +/- and +/+ animals, TGFalpha -/- mice have a pronounced waviness of the coat. Histological examination of the skin from TGFalpha -/- mice reveals a dramatic derangement of hair follicles. Mice with a disrupted TGFalpha gene also have curly whiskers, first evident on the day of birth. The phenotype of TGFalpha -/- mice is remarkably similar to that of the mouse mutant waved-1 (wa-1). Offspring resulting from crosses between TGFalpha -/- and wa-1 mice display the curly whisker-coat phenotype, indicating that the basis of the wa-1 phenotype is a mutation in the TGFalpha gene. These observations suggest that TGFalpha plays a pivotal role in determining skin architecture and in regulating hair development.