Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation
Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation
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DOI：
10.1016/s0024-3205(02)01853-2
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发表时间：
2002-09-06
期刊：
影响因子：
6.1
通讯作者：
Scharpé, S
中科院分区：
文献类型：
--
作者：
Maes, M;Verkerk, R;Scharpé, S
现在有一些证据表明，i）血浆色氨酸（5-羟色胺的前体）的可用性在妊娠末期和分娩后的前几天显著低于非妊娠女性; ii）妊娠和产褥期早期都伴随着炎症反应系统的激活。本研究的目的是检查妊娠和分娩对血浆犬尿氨酸的影响，犬尿氨酸是促炎细胞因子诱导吲哚胺-2，3双加氧酶（IDO）后合成的主要色氨酸分解代谢产物。我们测量了健康、非妊娠和妊娠妇女在分娩后1天和3天的血浆犬尿氨酸和色氨酸以及免疫标志物，如血清白细胞介素-6（IL-6）、IL-8和白血病抑制因子受体（LIF-R）。妊娠女性在期末时的血浆犬尿氨酸显著低于非妊娠女性，这可能归因于期末时血浆色氨酸较低。犬尿氨酸/色氨酸（K/T）商数在妊娠妇女在期末和产褥期早期显著高于非妊娠妇女。在产褥期早期，血浆犬尿氨酸和K/T商数显著增加。在产褥期焦虑和抑郁评分显著增加的女性中，血浆犬尿氨酸和K/T商数的增加显著更明显。犬尿氨酸和K/T比值从足月末到产褥早期的变化与免疫指标的变化有显著相关性。结论：1）足月时较低的血浆犬尿氨酸是较低的血浆色氨酸的结果; 2）足月时和产褥期早期K/T商数的增加表明炎症诱导的犬尿氨酸途径中色氨酸沿着降解;产褥期早期的抑郁和焦虑症状，（因果关系）与色氨酸转化为犬尿氨酸的催化剂增加有关，这是一种可能由免疫激活引起的现象。(C)2002年由Elsevier Science Inc.出版
There is now some evidence that i) the availability of plasma tryptophan, the precursor of serotonin, is significantly lower in pregnant women at the end of term and the first few days after delivery than in nonpregnant women; and ii) both pregnancy and the early puerperium are accompanied by activation of the inflammatory response system. The aims of the present study were to examine the effects of pregnancy and delivery on plasma kynurenine, a major tryptophan catabolite synthesized after induction of indoleamine-2, 3 dioxygenase (IDO) by pro-inflammatory cytokines. We measured plasma kynurenine and tryptophan and immune markers, such as serum interleukin-6 (IL-6), IL-8 and the leukemia inhibitory factor-receptor (LIF-R) in healthy, nonpregnant and pregnant women at the end of term and one and three days after delivery. Plasma kynurenine was significantly lower in pregnant women at the end of term than in nonpregnant women, findings which may be attributed to lower plasma tryptophan at the end of term. The kynurenine/tryptophan (K/T) quotient was significantly higher in the pregnant women at the end of term and in the early puerperium than in nonpregnant women. In the early puerperium there was a significant increase in plasma kynurenine and the K/T quotient. The increases in plasma kynurenine and the K/T quotient were significantly more pronounced in women whose anxiety and depression scores significantly increased in the puerperium. The changes from the end of term to the early puerperium in plasma kynurenine and the K/T quotient were significantly related to those in the immune markers. It is concluded that 1) lower plasma kynurenine at the end of term is the consequence of lower plasma tryptophan; 2) the increased K/T quotient at the end of term and in the early puerperium indicates inflammation-induced degradation of tryptophan along the kynurenine pathway; and 3) that depressive and anxiety symptoms in the early puerperium are (causally) related to an increased catabolism of tryptophan into kynurenine, a phenomenon which probably results from immune activation. (C) 2002 Published by Elsevier Science Inc.