Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy
Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy
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DOI：
10.1038/75015
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发表时间：
2000-05-01
期刊：
影响因子：
82.9
通讯作者：
Nagler-Anderson, C
中科院分区：
文献类型：
--
作者：
Fox, JG;Beck, P;Nagler-Anderson, C
幽门螺杆菌与胃炎和胃癌有因果关系。一些感染率较高的发展中国家的胃癌发病率较高，而在其他国家，胃癌发病率较低。 1 型 T 辅助细胞介导的螺杆菌诱发的胃炎和胃萎缩的进展可能受到并发寄生虫感染的调节。在这里，在同时感染蠕虫的小鼠中，尽管存在慢性炎症和高螺杆菌定植，但与螺杆菌相关的胃萎缩仍显着减少。这与 1 型 T 辅助细胞胃炎症反应相关的细胞因子和趋化因子 mRNA 的大幅减少有关。因此，并发肠道蠕虫感染可以减轻胃萎缩（一种癌前病变）。
Helicobacter pylori is causally associated with gastritis and gastric cancer. Some developing countries with a high prevalence of infection have high gastric cancer rates, whereas in others, these rates are low. The progression of helicobacter-induced gastritis and gastric atrophy mediated by type 1 T-helper cells may be modulated by concurrent parasitic infection. Here, in mice with concurrent helminth infection, helicobacter-associated gastric atrophy was reduced considerably despite chronic inflammation and high helicobacter colonization. This correlated with a substantial reduction in mRNA for cytokines and chemokines associated with a gastric inflammatory response of type 1 T-helper cells. Thus, concurrent enteric helminth infection can attenuate gastric atrophy, a premalignant lesion.