Computational tools for clinical support: a multi-scale compliant model for haemodynamic simulations in an aortic dissection based on multi-modal imaging data.
Computational tools for clinical support: a multi-scale compliant model for haemodynamic simulations in an aortic dissection based on multi-modal imaging data.
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DOI：
10.1098/rsif.2017.0632
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Díaz-Zuccarini V
中科院分区：
文献类型：
--
作者：
Bonfanti M;Balabani S;Greenwood JP;Puppala S;Homer-Vanniasinkam S;Díaz-Zuccarini V
主动脉夹层（AD）是一种发病率和死亡率很高的血管疾病。计算流体动力学（CFD）可以提供对AD进展的洞察，并帮助临床决策;然而，过于简化的建模假设和高计算成本会损害信息的准确性，并阻碍临床翻译。为了克服这些局限性，开发了一种结合Windkessel边界条件并考虑壁顺应性的患者特定CFD多尺度方法，并用于研究AD患者。采用一种新的移动边界算法来捕获壁位移，并使用丰富的体内临床数据集来调整模型参数和进行验证。计算机模拟和体内数据之间的比较表明，这种方法成功地捕获了患者特定AD的流量和压力波，并且能够预测假腔（FL）中的压力，这是该疾病临床管理的关键变量。结果显示，低和振荡壁切应力的区域，以及FL中预测的较高舒张压，可能表明扩张的风险。这项研究，在工程和医学的接口，演示了一个相对简单和计算效率高的方法来解释动脉变形和波传播现象的三维模型AD，代表了一个前进的一步，在使用CFD作为一个潜在的工具AD管理和临床支持。
Aortic dissection (AD) is a vascular condition with high morbidity and mortality rates. Computational fluid dynamics (CFD) can provide insight into the progression of AD and aid clinical decisions; however, oversimplified modelling assumptions and high computational cost compromise the accuracy of the information and impede clinical translation. To overcome these limitations, a patient-specific CFD multi-scale approach coupled to Windkessel boundary conditions and accounting for wall compliance was developed and used to study a patient with AD. A new moving boundary algorithm was implemented to capture wall displacement and a rich in vivo clinical dataset was used to tune model parameters and for validation. Comparisons between in silico and in vivo data showed that this approach successfully captures flow and pressure waves for the patient-specific AD and is able to predict the pressure in the false lumen (FL), a critical variable for the clinical management of the condition. Results showed regions of low and oscillatory wall shear stress which, together with higher diastolic pressures predicted in the FL, may indicate risk of expansion. This study, at the interface of engineering and medicine, demonstrates a relatively simple and computationally efficient approach to account for arterial deformation and wave propagation phenomena in a three-dimensional model of AD, representing a step forward in the use of CFD as a potential tool for AD management and clinical support.
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DOI：
10.1136/heartjnl-2015-308044
发表时间：
2016-01
期刊：
Heart (British Cardiac Society)
影响因子：
--
作者：
Morris PD;Narracott A;von Tengg-Kobligk H;Silva Soto DA;Hsiao S;Lungu A;Evans P;Bressloff NW;Lawford PV;Hose DR;Gunn JP
通讯作者：
Gunn JP
影响因子：
2.4
作者：
Tse, Kwong Ming;Chiu, Peixuan;Ho, Pei
通讯作者：
Ho, Pei
DOI：
10.1115/1.2895692
发表时间：
1994-02-01
影响因子：
1.7
作者：
MOORE, JE;KU, DN
通讯作者：
KU, DN
影响因子：
3.8
作者：
Gallo, D.;De Santis, G.;Morbiducci, U.
通讯作者：
Morbiducci, U.
关于在多尺度，主体血流动力学特定主题模型中建模假设的影响。
DOI：
10.1098/rsif.2016.0073
发表时间：
2016-06
期刊：
Journal of the Royal Society, Interface
影响因子：
--
作者：
Alastruey J;Xiao N;Fok H;Schaeffter T;Figueroa CA
通讯作者：
Figueroa CA