Direct analysis of phthalate esters in vegetable oils by means of comprehensive two-dimensional gas chromatography combined with triple quadrupole mass spectrometry
Direct analysis of phthalate esters in vegetable oils by means of comprehensive two-dimensional gas chromatography combined with triple quadrupole mass spectrometry
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DOI：
10.1016/j.foodchem.2022.133721
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发表时间：
2022-07-20
期刊：
影响因子：
8.8
通讯作者：
Tranchida, Peter Q.
中科院分区：
文献类型：
--
作者：
Arena, Alessia;Zoccali, Mariosimone;Tranchida, Peter Q.
邻苯二甲酸酯(PAE)，又称邻苯二甲酸酯，具有多种工业应用，主要与其增加塑料柔软性、柔韧性和耐用性有关。在毒理学方面，几项研究表明，邻苯二甲酸酯会作为内分泌干扰物，它们与几种形式的癌症有关。鉴于食品中邻苯二甲酸酯类化合物的分析具有挑战性，本研究的目的是建立一种简单、直接、无需制样(仅用溶剂稀释)的分析植物油中目标邻苯二甲酸酯类化合物的方法，采用低温调制全二维气相色谱-三重四极杆质谱联用。方法重现性好，定量限0.06~2.10 mg/kg，准确度-9.2~10.4%，基质效应-4~78%。该方法已用于27种植物油的分析。
Phthalic acid esters (PAEs), known as phthalates, have a variety of industrial applications, mainly related to their ability to increase plastic softness, flexibility, and durability. With regard to toxicological aspects, several studies suggest that phthalates would act as endocrine-disrupting chemicals, and they have been correlated to several forms of cancer. Since the analysis of PAEs in food is challenging, the aim of this study was the development of a simple and direct method, with no sample preparation (only dilution with solvent), for the analysis of targeted phthalates in vegetable oils, by using cryogenic-modulation comprehensive two-dimensional gas chromatography combined with triple quadrupole mass spectrometry. The method was characterized by good repeatability values, limit of quantification values ranging between 0.06 and 2.10 mg/kg, accuracy values ranging from -9.2 to 10.4%, and a matrix effect ranging from -4 to 78%. The developed technique was used for the analysis of 27 vegetable oils.