Dissociable effects of cingulate and medial frontal cortex lesions on stimulus-reward learning using a novel Pavlovian autoshaping procedure for the rat: Implications for the neurobiology of emotion
Dissociable effects of cingulate and medial frontal cortex lesions on stimulus-reward learning using a novel Pavlovian autoshaping procedure for the rat: Implications for the neurobiology of emotion
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DOI：
10.1037/0735-7044.111.5.908
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发表时间：
1997-10-01
影响因子：
1.9
通讯作者：
Robbins, TW
中科院分区：
文献类型：
--
作者：
Bussey, TJ;Everitt, BJ;Robbins, TW
喹啉酸诱导的前扣带皮层、后扣带皮层和内侧额叶皮层损伤对刺激奖励学习的影响通过一种新型巴甫洛夫自成形程序进行了研究，该程序允许向大鼠自动呈现计算机图形刺激（T. J. Bussey、J. L. Muir 和 T. W. Robbins，1994）。白色垂直矩形仅呈现在计算机屏幕的左侧或右侧。这些条件刺激之一（CS+）总是伴随着蔗糖颗粒的呈现；另一个是CS-，之后从来没有奖励。经过训练，老鼠比 CS- 更频繁地接近 CS+。前扣带皮层受损的大鼠未能表现出正常的辨别方法，与假手术对照组相比，对 CS 的接近明显更多。内侧额叶皮层受损的大鼠正常完成任务，但整体接近潜伏期较长。后扣带皮层损伤不影响采集。
The effects of quinolinic acid-induced lesions of the anterior cingulate, posterior cingulate, and medial frontal cortices on stimulus-reward learning were investigated with a novel Pavlovian autoshaping procedure in an apparatus allowing the automated presentation of computer-graphic stimuli to rats (T. J. Bussey, J. L. Muir, & T. W. Robbins, 1994). White vertical rectangles mere presented on the left or the right of a computer screen. One of these conditioned stimuli (the CS+) was always followed by the presentation of a sucrose pellet; the other, the CS-, was never followed by reward. With training, rats came to approach the CS+ more often than the CS-. Anterior cingulate cortex-lesioned rats failed to demonstrate normal discriminated approach, making significantly more approaches to the CS-than did sham-operated controls. Medial frontal cortex-lesioned rats acquired the task normally but had longer overall approach latencies. Posterior cingulate cortex lesions did not affect acquisition.