HBV infection decreases risk of liver metastasis in patients with colorectal cancer: A cohort study
HBV infection decreases risk of liver metastasis in patients with colorectal cancer: A cohort study
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DOI：
10.3748/wjg.v17.i6.804
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发表时间：
2011-02-14
影响因子：
4.3
通讯作者：
Xu, Rui-Hua
中科院分区：
文献类型：
--
作者：
Qiu, Hai-Bo;Zhang, Li-Yi;Xu, Rui-Hua
目的：探讨乙型肝炎病毒（HBV）感染对结直肠癌肝转移的影响。方法：本研究共纳入2001年1月至2005年3月期间的1298例结直肠癌患者。采用酶联免疫吸附试验检测结直肠癌血清 HBV 标志物。将患者分为研究组（感染）和对照组（非感染）。比较两组患者的临床特征。结果：1298例结直肠癌患者中，319例发现肝转移。研究组肝转移发生率显着低于对照组（14.2% vs 28.2%，P < 0.01）。 HBV感染显着降低肝转移风险[风险比（HR）：0.50，95%置信区间（95% CI）：0.38-0.66]，但研究组肝外转移发生率显着高于对照组（31.9% vs 17.0%，P < 0.01）。慢性乙型肝炎组的HR最低（HR：0.29，95％CI：0.12-0.72）。研究组肝转移病灶数量明显少于对照组，且手术切除率较高。但两组生存率无显着差异（P=0.95）。结论：HBV感染降低结直肠癌患者肝转移风险，提高肝转移病灶的手术切除率。 (C)2011年百事登。版权所有。
AIM: To evaluate the effect of hepatitis B virus (HBV) infection on liver metastasis of colorectal cancer.METHODS: A total of 1298 colorectal cancer patients were recruited from January 2001 to March 2005 in this study. Enzyme-linked immunosorbent assay was used to test serum HBV markers for colorectal cancer. Patients were divided into study (infection) group and control (non-infection) group. Clinical features of patients in two groups were compared.RESULTS: Liver metastasis was found in 319 out of the 1298 colorectal cancer patients. The incidence of liver metastasis was significantly lower in study group than in control group (14.2% vs 28.2%, P < 0.01). HBV infection significantly decreased the risk of liver metastasis [hazard ratio (HR): 0.50, 95% confidence interval (95% CI): 0.38-0.66], but the incidence of extrahepatic metastasis was significantly higher in study group than in control group (31.9% vs 17.0%, P < 0.01). The HR was the lowest in chronic hepatitis B group (HR: 0.29, 95% CI: 0.12-0.72). The number of liver metastatic lesions was significantly less in study group than in control group with a higher surgical resection rate. However, no significant difference was found in survival rate between the two groups (P = 0.95).CONCLUSION: HBV infection decreases the risk of liver metastasis in patients with colorectal cancer and elevates the surgical resection rate of liver metastatic lesions. (C) 2011 Baishideng. All rights reserved.