Sucrose and quinine intake by maternally-deprived and control rhesus monkeys
Sucrose and quinine intake by maternally-deprived and control rhesus monkeys
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DOI：
10.1016/s0166-4328(00)00173-x
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发表时间：
2000-07-01
影响因子：
2.7
通讯作者：
Halaris, A
中科院分区：
文献类型：
--
作者：
Paul, IA;English, JA;Halaris, A
临床抑郁症的特征通常是对以前令人愉快的活动失去兴趣或快乐。快感缺乏的类似物已经在大鼠身上建立起来，但这种现象在其他物种中的普遍性尚不清楚。失去母亲的恒河猴表现出广泛的行为异常，这些异常可以通过慢性抗抑郁药物治疗逆转。我们测试了母体剥夺猕猴与对照猕猴对甜味水（7种蔗糖浓度）或苦味水（4种奎宁浓度）和白水的消耗情况，以评估非人类灵长类动物抑郁症模型的快感缺乏迹象。所有的猴子都比自来水喝更多的甜味水，但与对照组相比，失去母亲的猴子对甜味水的偏好降低了。然而，被剥夺母亲的动物比对照组喝了更多的苦水。基线液体消耗量没有差异。数据表明，动物模型中的“快感缺乏症”可能继发于对刺激的反应性普遍减弱，而不是对刺激的食欲特性的反应性单一降低。我们的结论是，母性剥夺的恒河猴没有表现出味觉快感缺乏的迹象，而是对味觉刺激不敏感。(C) 2000 Elsevier Science B.V.版权所有
Clinical depression is often characterized by a loss of interest or pleasure in formerly enjoyable activities. Analogs of anhedonia are established in rats, but the generality of this phenomenon to other species is unknown. Maternally-deprived rhesus macaques show a wide range of behavioral abnormalities that are reversed by chronic antidepressant treatment. We tested consumption by maternally deprived versus control macaques of sweetened (seven sucrose concentrations) or bitter water (four quinine concentrations) versus plain water to evaluate a non-human primate model of depression for signs of anhedonia. All monkeys consumed more sweetened than tap water, but maternally-deprived monkeys had a diminished preference for sweetened water than did controls. However, maternally deprived animals consumed more bitter water than did controls. Baseline fluid consumption did not differ. The data suggest that 'anhedonia' in animal models may be secondary to a generally attenuated responsiveness to stimuli, rather than a unitary reduction in responsiveness to the appetitive properties of stimuli. We conclude that maternally-deprived rhesus monkeys do not display gustatory signs of anhedonia, but rather of insensitivity to gustatory stimuli. (C) 2000 Elsevier Science B.V. All rights reserved.