Effect of photic injury on the retinal tissues.
Effect of photic injury on the retinal tissues.
复制标题
光损伤对视网膜组织的影响。
DOI：
10.1016/s0161-6420(83)80023-2
复制
发表时间：
1983
期刊：
影响因子：
13.7
通讯作者：
Woodford,BJ
中科院分区：
文献类型：
--
作者：
Tso,MO;Woodford,BJ
为了研究视网膜光损伤中的组织损伤，用间接检眼镜照射恒河猴的黄斑和后极部。在损伤的急性期，血-视网膜屏障的破坏似乎是视网膜色素上皮损伤的早期和敏感的指标，光感受器板层的环-GMP-磷酸二酯酶失活。对这些病变进行了2~5年的随访。在这种光性黄斑病变的慢性退行性阶段，可观察到血-视网膜屏障的局限性慢性失代偿和视网膜下色素上皮新生血管。抗坏血酸在轻度光损伤中可能具有保护作用。
In order to study the tissue damages in photic injury of the retina, the macula and posterior pole of the rhesus monkey were exposed to the light of an indirect ophthalmoscope. During the acute phase of the injury, disruption of the blood-retinal barrier appeared to be an early and sensitive indicator of retinal pigment epithelial damage and cyclic-GMP-phosphodiesterase of the photoreceptor lamella was inactivated. These lesions were followed for 2 to 5 years. Focal chronic decompensation of the blood-retinal barrier and subretinal pigment epithelial neovascularization were noted in the chronic degenerative phase of this photic maculopathy. A possible protective role of ascorbic acid in mild photic injury was proposed.