Anti-Tissue Antibodies Are Related to Lung Function in Chronic Obstructive Pulmonary Disease
Anti-Tissue Antibodies Are Related to Lung Function in Chronic Obstructive Pulmonary Disease
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DOI：
10.1164/rccm.201001-0029oc
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发表时间：
2011-04-15
影响因子：
24.7
通讯作者：
Agusti, Alvar
中科院分区：
文献类型：
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作者：
Nunez, Belen;Sauleda, Jaume;Agusti, Alvar
依据：慢性阻塞性肺疾病（COPD）是一种多组分疾病。自身免疫可能参与COPD的发病机制。目的：本研究调查COPD患者循环抗核抗体（ANA）和抗组织抗体（AT）的患病率及其与疾病的几个组成部分的关系。检测肺功能，免疫荧光法测定血清抗核抗体（ANA）和抗凝血酶（AT）滴度，采用高灵敏度散射比浊法测定328例临床稳定期COPD患者和67例健康对照者的血清C反应蛋白（CRP）水平。结果：ANA和AT滴度异常的患病率分别为34%和26%，对照组分别为3%和6%。在21%的COPD患者中，AT水平大于或等于1：320，并且与气流限制和气体转移障碍的严重程度独立相关（P，0.05）。ANA或AT滴度均与体重指数、当前吸烟状况、吸入性类固醇的使用、Charlson指数或血清C-反应蛋白values.Conclusions：四分之一至三分之一临床稳定的COPD患者存在循环ANA和AT滴度异常。所观察到的AT和肺功能之间的关系支持自身免疫在COPD发病机制中的作用。
Rationale: Chronic obstructive pulmonary disease (COPD) is a multicomponent disease. Autoimmunity can contribute to the pathogenesis of COPD.Objectives: This study investigates the prevalence of circulating antinuclear antibodies (ANA) and anti-tissue (AT) antibodies, two common markers of autoimmunity, in COPD and their relationship with several components of the disease.Methods: We determined lung function, the serum titers of ANA and AT by immunofluorescence, and the serum levels of C-reactive protein (CRP) by high sensitivity nephelometry in 328 patients with clinically stable COPD and in 67 healthy controls recruited in the PAC-COPD study. Multiple linear and logistic regression analysis was used to analyze results.Measurements and Main Results: The prevalence of abnormal ANA and AT titers was 34% and 26% in patients and 3% and 6% in controls, respectively. Levels of AT greater than or equal to 1: 320 were seen in 21% of patients with COPD and were independently associated with the severity of airflow limitation and gas transfer impairment (P, 0.05). Neither ANA or AT titers was related to body mass index, current smoking status, use of inhaled steroids, the Charlson index, or serum C-reactive protein values.Conclusions: Between a quarter and a third of patients with clinically stable COPD present abnormal titers of circulating ANA and AT. The observed relationship between AT and lung function supports a role for autoimmunity in the pathogenesis of COPD.