Discovery of a natural thiamine adenine nucleotide
Discovery of a natural thiamine adenine nucleotide
复制标题
DOI：
10.1038/nchembio867
复制
发表时间：
2007-04-01
影响因子：
14.8
通讯作者：
Wins, Pierre
中科院分区：
文献类型：
--
作者：
Bettendorff, Lucien;Wirtzfeld, Barbara;Wins, Pierre
几个重要的辅因子是腺嘌呤核苷酸与维生素作为催化部分。在这里，我们报告发现的第一个腺嘌呤核苷酸含有维生素B1：腺苷硫胺素三磷酸（AThTP，1），或硫胺素ATP。我们在大肠杆菌中发现了AThTP，并发现它在响应碳饥饿时特异性地积累，从而作为信号而不是辅因子。我们在酵母菌和动植物组织中检测到了少量。
Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues.